Establishing Functionally Segregated Dopaminergic Circuits

Medicine, Psychiatry, Neurology, Life Sciences, Cell Biology,
dopaminergic circuits   functional segregation   neuronal development   molecular mechanisms   neuropsychiatric disorders  

Functional Segregation of Dopaminergic Neural Circuits and Their Developmental Mechanisms Academic Background Dopamine is a crucial neurotransmitter in the brain, regulating various physiological functions, including motor control, emotional regulation, motivation, learning, and memory. Dopaminergic neurons are primarily located in the midbrain, an...

Neocortical Somatostatin Neuron Diversity in Cognition and Learning

Medicine, Neurology,
neocortex   somatostatin neurons   cognition   learning   neuronal diversity   plasticity   cortical function  

Academic Background In the mammalian neocortex, somatostatin (SST)-expressing neurons are a major class of inhibitory interneurons that exhibit diversity in electrophysiology and morphology, and are involved in various cognitive functions such as learning, memory, and sensory processing. However, despite extensive research on the diversity of SST n...

Peripheral, Central, and Chemotherapy-Induced Neuropathic Changes in Pancreatic Cancer

Medicine, Neurology, Oncology,
pancreatic cancer   neuropathic changes   chemotherapy-induced neuropathy   neural remodeling   neuropathic pain  

Neuropathic Changes in Pancreatic Cancer Academic Background Pancreatic cancer is one of the most lethal cancers today, characterized by late diagnosis and high aggressiveness. Despite some progress in diagnosis and treatment in recent years, the five-year survival rate for pancreatic cancer remains extremely low, at only around 12%. The pathogenes...

Proteomic Analysis Reveals Distinct Cerebrospinal Fluid Signatures Across Genetic Frontotemporal Dementia Subtypes

Medicine, Medical Laboratory Science, Neurology, Life Sciences, Biochemistry, Genetics,
proteomics   frontotemporal dementia   cerebrospinal fluid   genetic mutations   neurodegenerative diseases  

Academic Background Frontotemporal Dementia (FTD) is a group of progressive neurodegenerative diseases characterized primarily by behavioral changes, language impairment, or motor dysfunction. Although the incidence of FTD is lower than that of Alzheimer’s Disease (AD), it remains one of the leading causes of early-onset dementia. The molecular bas...

Antisense Oligonucleotide–Mediated MSH3 Suppression Reduces Somatic CAG Repeat Expansion in Huntington’s Disease iPSC–Derived Striatal Neurons

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
Huntington's disease   CAG repeat expansion   antisense oligonucleotide   iPSC-derived neurons   MSH3 protein  

Therapeutic Potential of ASO-Mediated MSH3 Suppression in Huntington’s Disease Academic Background Huntington’s disease (HD) is a neurodegenerative disorder caused by abnormal expansion of the CAG repeat sequence in the huntingtin gene (HTT). This expanded CAG repeat continues to expand somatically over time, driving the onset and progression of th...

Amyloid-Associated Hyperconnectivity Drives Tau Spread Across Connected Brain Regions in Alzheimer’s Disease

Medicine, Neurology,
Alzheimer's disease   tau spread   amyloid   neuronal hyperconnectivity   brain regions   neurodegeneration   functional connectivity  

Amyloid-Associated Hyperconnectivity Drives Tau Spread in Alzheimer’s Disease Academic Background Alzheimer’s Disease (AD) is a common neurodegenerative disorder characterized by the accumulation of amyloid-beta (Aβ) plaques and the abnormal aggregation and spread of tau protein in the brain. The traditional “amyloid cascade hypothesis” posits that...