The NOMPC ion channel hinge forms a gating spring that initiates mechanosensation

Medicine, Neurology, Life Sciences, Cell Biology, Biophysics,
mechanosensation   ion channel   gating spring   molecular dynamics   NOMPC  

NOMPC Ion Channel Hinge Forms Gating Spring to Initiate Mechanosensation Academic Background Mechanosensation is the process by which organisms perceive external mechanical stimuli and convert them into electrical signals. This process plays a crucial role in touch, hearing, gravity perception, and the movement of internal organs and limbs. The ini...

Propagation of Pathologic α-Synuclein from Kidney to Brain May Contribute to Parkinson’s Disease

Medicine, Urology, Nephrology, Neurology, Life Sciences,
Parkinson’s disease   α-synuclein   renal function   pathologic propagation   neurodegenerative disorders  

Pathological Link Between Kidney Disease and Parkinson’s Disease Academic Background Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by the abnormal aggregation of α-synuclein (α-syn) in the brain, forming Lewy bodies (LBs) and Lewy neurites (LNs). In recent years, increasing evidence suggests that the pathological agg...

Aberrant Splicing in Huntington’s Disease Accompanies Disrupted TDP-43 Activity and Altered m6A RNA Modification

Medicine, Neurology, Life Sciences, Cell Biology, Genetics,
Huntington’s Disease   TDP-43   m6A RNA modification   aberrant splicing   neurodegenerative disorder  

Aberrant Splicing in Huntington’s Disease Accompanies Disrupted TDP-43 Activity and Altered m6A RNA Modification Academic Background Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder characterized by motor, cognitive, and psychiatric symptoms. The disease is caused by a CAG repeat expansion in the HTT gene, leading to ab...

A Distinct Hypothalamus–Habenula Circuit Governs Risk Preference

Medicine, Psychiatry, Neurology, Life Sciences, Cell Biology, Bioengineering, Biophysics,
risk preference   hypothalamus   habenula   decision-making   neural circuits  

Study on the Hypothalamus-Habenula Circuit Regulating Risk Preference Academic Background In complex and uncertain environments, animals need to assess risks to make survival-favorable decisions. When faced with safe and risky options, animals usually exhibit a strong preference for one option, which remains consistent over time. However, how this ...

A Large Field-of-View, Single-Cell-Resolution Two- and Three-Photon Microscope for Deep and Wide Imaging

A Large Field-of-View, Single-Cell-Resolution Two- and Three-Photon Microscope for Deep and Wide Imaging

Physics, Optics, Engineering, Electrical Engineering, Medicine, Neurology, Medical Imaging, Life Sciences, Bioengineering, Biophysics,
three-photon microscopy   two-photon microscopy   large field of view   brain imaging   DeepScope  

Large field-of-view, single-cell-resolution two- and three-photon microscope for deep and wide imaging Research Background and Problem Statement Multiphoton microscopy (MPM) is a powerful tool for deep tissue imaging, especially in the study of brain function in vivo. However, while traditional two-photon microscopy (2PM) can achieve a larger imagi...

Establishing Functionally Segregated Dopaminergic Circuits

Medicine, Psychiatry, Neurology, Life Sciences, Cell Biology,
dopaminergic circuits   functional segregation   neuronal development   molecular mechanisms   neuropsychiatric disorders  

Functional Segregation of Dopaminergic Neural Circuits and Their Developmental Mechanisms Academic Background Dopamine is a crucial neurotransmitter in the brain, regulating various physiological functions, including motor control, emotional regulation, motivation, learning, and memory. Dopaminergic neurons are primarily located in the midbrain, an...