Reliability of Central Vein Sign Imaging with 3T FLAIR* in a Multicenter Study

Medicine, Neurology, Medical Imaging,
central vein sign   FLAIR*   multicenter study   multiple sclerosis   MRI   gadolinium contrast   diagnostic biomarker  

Reliability of Central Vein Sign Imaging with 3T FLAIR* in a Multicenter Study Academic Background Multiple Sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by the formation of white matter lesions (WMLs). Magnetic Resonance Imaging (MRI) is a crucial tool for diagnosing and monitoring MS, particularly T2...

Larger Perfusion Mismatch Volume is Associated with Longer Hospital Length of Stay in Medium Vessel Occlusion Stroke

Medicine, Neurology, Medical Imaging,
perfusion mismatch   medium vessel occlusion   stroke   length of stay   CT perfusion   mechanical thrombectomy   neuroimaging  

Larger Perfusion Mismatch Volume is Associated with Longer Hospital Length of Stay in Medium Vessel Occlusion Stroke Academic Background Stroke is the second leading cause of death globally, imposing a significant burden on both patients and healthcare systems. Prolonged hospital length of stay (LOS) is closely associated with adverse clinical outc...

Living in Biological Darkness II: Impact of Winter Habitual Daytime Light on Night-time Sleep

Medicine, Psychiatry, Neurology,
biological darkness   depression marker   habitual daytime lighting   REM latency   sleep   slow wave sleep  

The Impact of Winter Urban Light on Night-Time Sleep Background Light and darkness are the primary environmental factors regulating human circadian rhythms. In natural environments, humans are exposed to light levels ranging from 3,000 lux (cloudy winter sky) to 100,000 lux (clear sky). However, in modern urban environments, especially during winte...

Causal Relationship Between Intestinal Microbiota, Inflammatory Cytokines, Peripheral Immune Cells, Plasma Metabolome and Parkinson's Disease: A Mediation Mendelian Randomization Study

Medicine, Neurology, Life Sciences, Biochemistry, Microbiology,
intestinal microbiota   inflammatory cytokines   mendelian randomization study   Parkinson's disease   peripheral immune cells   plasma metabolome   mediation analysis  

Causal Relationship Between Gut Microbiota and Parkinson’s Disease Academic Background Parkinson’s Disease (PD) is a common neurodegenerative disorder characterized by motor dysfunction (such as bradykinesia, muscle rigidity, and resting tremors) and non-motor symptoms (such as olfactory impairment, cognitive decline, and sleep disturbances). Altho...

Hemispheric Asymmetry of Intracortical Myelin Orientation in the Mouse Auditory Cortex

Medicine, Neurology, Life Sciences,
auditory cortex   myelination   hemispheric asymmetry   light sheet microscopy   mice   sex differences   neuronal distribution  

Hemispheric Asymmetry of Myelin Orientation in the Mouse Auditory Cortex Academic Background The mammalian brain exhibits inherent asymmetry, which is particularly evident in the motor system and acoustic communication. For example, both mice and humans show hemispheric differences in auditory processing. This asymmetric organization allows the bra...

Pallidal Spike-Train Variability and Randomness are the Most Important Signatures to Classify Parkinson's Disease and Cervical Dystonia

Medicine, Neurology, Life Sciences,
Parkinson's disease   cervical dystonia   globus pallidus   spike-train variability   randomness   deep brain stimulation   neuronal activity  

Classification Study of Parkinson’s Disease and Cervical Dystonia Academic Background Parkinson’s Disease (PD) and Cervical Dystonia (CD) are two common movement disorders whose pathological mechanisms are closely related to abnormal neuronal activity in the basal ganglia. The basal ganglia are a crucial brain structure for motor control, with the ...