Super-Resolution Imaging of Fast Morphological Dynamics of Neurons in Behaving Animals

Medicine, Neurology, Medical Imaging, Life Sciences, Biophysics,
super-resolution imaging   neuronal morphological dynamics   behaving animals   structured illumination microscopy   neural plasticity  

Super-Resolution Imaging Reveals New Advances in Neural Morphodynamics in Mouse Brains: Dynamic Observations in Head-Fixed Awake Animals Background In the field of neuroscience, understanding the morphological changes and functional dynamics of neurons is key to deciphering how the brain processes information and sustains network plasticity. Despit...

A Temporal Cortex Cell Atlas Highlights Gene Expression Dynamics During Human Brain Maturation

Medicine, Neurology, Life Sciences, Cell Biology, Genetics,
temporal cortex   single-nucleus RNA sequencing   brain maturation   gene expression   cell subtypes   cognition   synaptic plasticity  

Gene Expression Dynamics During Human Brain Maturation: A Novel Temporal Cortex Cell Atlas Academic Background The development and maturation of the human brain are critical areas in neuroscience, though many mysteries remain unresolved. Guided by changes in gene expression, the human brain undergoes a prolonged and complex postnatal maturation pro...

ONIX: A Unified Open-Source Platform for Multimodal Neural Recording and Perturbation During Naturalistic Behavior

Medicine, Neurology, Life Sciences, Bioengineering,
neural recording   naturalistic behavior   open-source platform   multimodal   low latency   mouse experiments   neuroscience  

ONIX: An Open-Source Platform for Multimodal Neural Recording and Perturbation During Naturalistic Behavior Research Background and Significance In recent years, significant advances have been made in large-scale neural population recording technology and studies on animal behavior in the field of neuroscience. However, these two demands often conf...

The Development and Application of an Engineered Direct Electron Transfer Enzyme for Continuous Levodopa Monitoring

Chemistry, Analytical Chemistry, Medicinal Chemistry, Medicine, Neurology, Life Sciences, Biochemistry, Bioengineering,
levodopa   Parkinson's disease   direct electron transfer enzyme   biosensor   continuous monitoring  

Development of an Engineered Direct Electron Transfer Enzyme for Continuous Levodopa Monitoring Background Parkinson’s Disease (PD) is a chronic neurodegenerative disease that affects millions of people worldwide. It is characterized by the loss of dopaminergic neurons in the substantia nigra and the presence of α-synuclein aggregations forming Lew...

Resolving Native GABAA Receptor Structures from the Human Brain

Medicine, Neurology, Life Sciences, Biochemistry, Biophysics,
GABAA receptor   structural analysis   epilepsy   cryo-electron microscopy   drug binding   neurotransmitter   human brain  

Resolving Native GABAA Receptor Structures from the Human Brain: A Breakthrough Study Academic Background GABAA receptors (γ-aminobutyric acid type A receptors) are among the most important inhibitory neurotransmitter receptors in the brain, responsible for regulating fast inhibitory signaling in neurons. These receptors are not only key drug targe...

Experience-Dependent Dopamine Modulation of Male Aggression

Medicine, Psychiatry, Neurology,
dopamine   aggression   ventral tegmental area   neural mechanisms   male mice   experience-dependent   neural circuits  

Experience-Dependent Dopamine Modulation of Male Aggression in Mice Academic Background Aggression is a common social behavior in the animal kingdom, crucial for territory defense, resource competition, and mate protection. Although the role of dopamine in regulating aggression has been extensively studied, its specific neural mechanisms remain unc...