Aging-induced tRNAglu-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
aging   tRNA-derived fragment   mitochondria   glutamate   cristae organization   memory decline  

Aging-induced trnaGlu-derived fragments disrupt glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization Academic Background Mitochondrial cristae are inward protrusions of the inner mitochondrial membrane that undergo significant morphological changes during aging. However, the molecular mechanisms leading to th...

Imaging Brain Glucose Metabolism In Vivo Reveals Propionate as a Major Anaplerotic Substrate in Pyruvate Dehydrogenase Deficiency

Medicine, Basic Medical Sciences, Neurology, Medical Imaging, Life Sciences, Biochemistry,
Brain Glucose Metabolism   Pyruvate Dehydrogenase Deficiency   Propionate   Imaging Phenotype   Ketogenic Diet  

Imaging Study of Brain Glucose Metabolism in Patients with Pyruvate Dehydrogenase Deficiency Background In modern mitochondrial medicine, evaluating the spectrum of brain diseases has been a limiting challenge. This limitation hinders our ability to understand the mechanisms behind the imaging phenotypes of the brains of mitochondrial disease patie...

Neuronal AMPK Regulates Microglial Lipid Droplet Accumulation in Tauopathy Brain

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
Neurons   AMPK   Lipid Droplets   Tauopathy   Microglia   Neuroinflammation   Lipid Metabolism  

Accumulation of Lipid Droplets in Microglia is Regulated by Neuronal AMPK Background and Research Question Alzheimer’s Disease (AD) is a common type of dementia characterized by neurofibrillary tangles and β-amyloid plaques. However, beyond these classical pathologies, changes in lipid metabolism are increasingly recognized as closely associated wi...

White Matter Microstructural Changes Using Ultra-Strong Diffusion Gradient MRI in Adult-Onset Idiopathic Focal Cervical Dystonia

Medicine, Neurology, Medical Imaging,
white matter   microstructural   MRI   cervical dystonia   adult-onset   idiopathic focal  

Study Report on White Matter Microstructure Changes in Adult-Onset Idiopathic Focal Cervical Dystonia Patients Scientists are dedicated to studying Adult-Onset Idiopathic Focal Cervical Dystonia (AOIFCD), the most common type of idiopathic dystonia in adults. This condition primarily manifests as abnormal neck muscle postures, often accompanied by ...

Prehospital Lactate Levels Obtained in the Ambulance and Prediction of 2-Day In-Hospital Mortality in Patients with Traumatic Brain Injury

Medicine, Emergency Medicine, Medical Laboratory Science, Neurology, Medical Imaging,
prehospital lactate levels   traumatic brain injury   in-hospital mortality   Glasgow Coma Scale   emergency care  

Research Report Background Overview Traumatic Brain Injury (TBI) is one of the leading causes of permanent disability and death worldwide. These disorders are dynamic and evolving, involving progressive brain injury and pathophysiological changes accompanied by multi-system damage. The severity of TBI is typically assessed using the Glasgow Coma Sc...

Long-term Dementia Risk in Parkinson Disease

Medicine, Geriatrics, Neurology, Life Sciences,
Parkinson's disease   dementia risk   long-term study   cognitive impairment   neurological disorders  

Study on the Long-Term Risk of Dementia in Parkinson’s Disease Background Parkinson’s Disease (PD) is a common neurodegenerative disorder primarily characterized by motor dysfunction. However, cognitive decline and Parkinson’s disease dementia (PDD) are also significant non-motor symptoms of PD. Although dementia occurs in approximately 80% of PD p...