Pathologic Substrates of Structural Brain Network Resilience and Topology in Parkinson Disease Decedents

Medicine, Basic Medical Sciences, Neurology, Medical Imaging, Life Sciences, Cell Biology, Biochemistry,
Parkinson's disease   brain network   α-synuclein   diffusion-weighted imaging   network resilience  

Scientific Paper News Report: Pathological Basis and Topological Properties of Structural Brain Networks in Parkinson’s Disease Patients Background and Research Objectives In Parkinson’s disease (PD), α-synuclein spreads between connected brain regions, leading to neuronal loss and brain network disruption. Using diffusion-weighted imaging (DWI), t...

Demonstration of Group-Level and Individual-Level Efficacy Using Time-to-Event Designs for Clinical Trials of Antiseizure Medications

Medicine, Medical Laboratory Science, Neurology,
antiseizure medications   clinical trials   time-to-event design   efficacy   epilepsy   safety   randomized controlled trial  

Time-to-Event Design in Clinical Trials and Efficacy of Anti-Epileptic Drugs at Group and Individual Levels Background The significance of anti-epileptic drugs (ASM) in treating refractory epilepsy cannot be ignored. However, the current parallel assignment, randomized, placebo-controlled trial (RCT) designs have been in use for many years, requiri...

Electroencephalography-Guided Anesthesia and Delirium in Older Adults after Cardiac Surgery

Medicine, Psychiatry, Geriatrics, Anesthesiology, Neurology, Cardiovascular System,
Electroencephalography   Anesthesia   Older Adults   Cardiac Surgery   Delirium  

EEG-Guided Anesthesia and Delirium in Elderly Patients After Cardiac Surgery Research Background Delirium is a common postoperative complication in elderly patients, particularly after cardiac surgery. Delirium not only leads to cognitive decline but also increases hospitalization time and medical costs. Current preventive measures are limited in e...

A Comprehensive Overview of NF1 Mutations in Iranian Patients

Medicine, Medical Laboratory Science, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
NF1   mutation   Iranian   whole-exome sequencing   genetic counseling  

Comprehensive Overview of Mutations in Neurofibromatosis Type 1 Among Iranian Patients Neurofibromatosis type 1 (NF1) is a hereditary disease caused by mutations in the NF1 gene, characterized by almost complete penetrance and high phenotypic variability. This study aims to identify NF1 mutations in Iranian patients using whole-genome exome sequenc...

Astaxanthin Rescues Memory Impairments in Rats with Vascular Dementia by Protecting Against Neuronal Death in the Hippocampus

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
vascular dementia   astaxanthin   Alzheimer’s disease   neurodegenerative diseases   neuronal apoptosis  

Astaxanthin Protects Hippocampal Neurons Against Memory Impairment Caused by Vascular Dementia in Rats Background Introduction Vascular Dementia (VAD) is a progressive cognitive disorder caused by cerebrovascular disease leading to cognitive decline. Current research shows that chronic cerebral hypoperfusion (CCH) and insufficient blood supply are ...

Evaluation of Neuroprotective Effect of Gut Microbe in Parkinson's Disease: An In Silico and In Vivo Approach

Medicine, Neurology, Life Sciences, Biochemistry, Immunology, Microbiology,
α-synuclein   gut microbes   metabolites   protein-protein interaction   therapeutic agent   parkinsonian mice model  

Study on the Protective Effects of Medicinal Microorganisms on Parkinson’s Disease Background Introduction Parkinson’s Disease (PD) is a progressive neurodegenerative disorder characterized by the death of dopaminergic neurons in the substantia nigra region of the brain. The aggregation of α-synuclein is a crucial factor in the pathogenesis of Park...