Predicting Outcomes in Esophageal Squamous Cell Carcinoma Using scRNA-seq and Bulk RNA-seq: A Model Development and Validation Study

Medicine, Oncology, Life Sciences, Cell Biology, Immunology,
Esophageal squamous cell carcinoma   Glucose metabolism   Immune infiltration   Prognosis   Single-cell RNA sequencing   Bulk RNA sequencing   Bioinformatics  

Prognostic Prediction Model for Esophageal Squamous Cell Carcinoma Based on Single-Cell RNA Sequencing and Bulk RNA Sequencing Research Background Esophageal Squamous Cell Carcinoma (ESCC) is one of the most common malignant tumors globally, particularly prevalent in East Asia. Despite existing treatment methods such as surgery, endoscopic resectio...

Evaluation of Treatment Outcomes Using DNLR and GNRI in Combination Therapy with Atezolizumab and Bevacizumab for Hepatocellular Carcinoma

Medicine, Hepatobiliary System, Oncology,
hepatocellular carcinoma   DNLR   GNRI   atezolizumab   bevacizumab   prognosis   immune checkpoint inhibitor  

Evaluation of Treatment Outcomes Using DNLR and GNRI in Combination Therapy for Hepatocellular Carcinoma Background Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide, particularly in Asia. Due to its lack of early symptoms, many patients are diagnosed at an advanced stage, making surgical resection unfeasible. In r...

Subtype-Specific Differences in Metabolic Profiles of Pancreatic Cancer Tumor Organoids

Medicine, Oncology, Life Sciences, Biochemistry,
Pancreatic cancer   Metabolic reprogramming   Glycolysis   Oxidative phosphorylation   Tumor organoids   Subtype-specific   Mitochondrial pyruvate carrier  

Metabolic Characteristics of Pancreatic Ductal Adenocarcinoma (PDAC) Subtypes Background Pancreatic Ductal Adenocarcinoma (PDAC) is a highly aggressive cancer with a five-year survival rate of only 13%, making it the third leading cause of cancer-related deaths. The aggressiveness and chemoresistance of PDAC are closely linked to its complex metabo...

Metabolism of Primary High-Grade Serous Ovarian Carcinoma (HGSOC) Cells under Limited Glutamine or Glucose Availability

Medicine, Obstetrics and Gynecology, Oncology,
High-Grade Serous Ovarian Carcinoma   Metabolic Flexibility   Oxidative Phosphorylation   Endoplasmic Reticulum Stress   Chemotherapy Resistance  

Metabolism of High-Grade Serous Ovarian Carcinoma (HGSOC) Cells Academic Background High-Grade Serous Ovarian Carcinoma (HGSOC) is the most common and aggressive subtype of epithelial ovarian cancer. Most patients are diagnosed at stage III or IV, with a 5-year survival rate ranging from 20% to 40%. Treatment for HGSOC typically involves surgical r...

PAF1/HIF1α Axis Rewires Glycolytic Metabolism to Fuel Aggressiveness of Pancreatic Cancer

Medicine, Oncology, Life Sciences, Biochemistry,
Pancreatic Cancer   Metabolic Reprogramming   Aerobic Glycolysis   PAF1/HIF1α Axis   Lactate Dehydrogenase A  

PAF1/HIF1α Axis Promotes Pancreatic Cancer Aggressiveness by Regulating Glycolytic Metabolism Background Pancreatic cancer (PC) is a highly aggressive malignant tumor, with pancreatic ductal adenocarcinoma (PDAC) being the most common type. Despite significant advancements in cancer treatment in recent years, the 5-year survival rate for pancreatic...

Silencing of STEAP3 Suppresses Cervical Cancer Cell Proliferation and Migration via JAK/STAT3 Signaling Pathway

Medicine, Oncology,
STEAP3   cervical cancer   JAK/STAT3 signaling pathway   cell proliferation   cell migration   DNA methylation   iron metabolism  

The Role and Mechanism of STEAP3 in Cervical Cancer Background Cervical cancer (CC) is the fourth most common cancer among women globally, with approximately 600,000 new cases and 300,000 deaths annually. Although the five-year survival rate for early-stage cervical cancer patients exceeds 85% through treatments such as surgery, radiotherapy, and c...