Circulating Extracellular Vesicles as Promising Biomarkers for Precision Diagnostics: A Perspective on Lung Cancer

Medicine, Respiratory System, Oncology, Life Sciences, Biochemistry, Bioengineering, Immunology, Genetics, Biophysics,
extracellular vesicles   lung cancer   liquid biopsy   biosensors   early detection   precision medicine   nanotechnology  

Exosomes as Biomarkers for Precision Diagnosis of Lung Cancer Academic Background Lung cancer is one of the leading causes of cancer-related deaths worldwide, with early diagnosis and precision treatment of non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) remaining significant challenges. Although traditional tissue biopsy is co...

Design of a Magnetic Nanoplatform Based on CD26 Targeting and HSP90 Inhibition for Apoptosis and Ferroptosis-Mediated Elimination of Senescent Cells

Design of a Magnetic Nanoplatform Based on CD26 Targeting and HSP90 Inhibition for Apoptosis and Ferroptosis-Mediated Elimination of Senescent Cells

Chemistry, Nanoscience, Medicinal Chemistry, Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology,
Iron oxide nanoparticles   CD26   HSP90 inhibitor   Drug-induced senescence   Skin cells   Senolysis  

Magnetic Nanoplatform Based on CD26 Targeting and HSP90 Inhibition for Apoptosis and Ferroptosis-Mediated Elimination of Senescent Cells Academic Background With the intensification of population aging, the accumulation of senescent cells is considered a significant hallmark of aging and age-related diseases. Senescent cells are not only associated...

Enhancing Gene Delivery to Breast Cancer with Highly Efficient siRNA Loading and pH-Responsive Small Extracellular Vesicles

Enhancing Gene Delivery to Breast Cancer with Highly Efficient siRNA Loading and pH-Responsive Small Extracellular Vesicles

Chemistry, Medicinal Chemistry, Chemical Engineering, Medicine, Oncology, Life Sciences, Biochemistry, Bioengineering, Genetics,
small extracellular vesicles   gene delivery   pH-responsive   graphene quantum dots   lysosomal escape   breast cancer   siRNA  

Enhancing Gene Delivery to Breast Cancer with Highly Efficient siRNA Loading and pH-Responsive Small Extracellular Vesicles Academic Background In recent years, small extracellular vesicles (sEVs) have become a hot topic in the field of drug delivery due to their natural origin and inherent homing properties. sEVs are lipid nanoparticles secreted b...

The Mevalonate Pathway Contributes to Breast Primary Tumorigenesis and Lung Metastasis

Medicine, Oncology,
mevalonate pathway   breast cancer   lung metastasis   Rho GTPases   cholesterol   gene expression   tumor recurrence  

Regulation of the Mevalonate Pathway in Breast Cancer and Its Role in Tumorigenesis and Lung Metastasis Background Introduction Breast cancer is one of the most common cancers among women worldwide, and its occurrence and metastasis mechanisms are complex, involving abnormal regulation of multiple signaling pathways and metabolic processes. In rece...

Platelet-Activating Factor: A Potential Therapeutic Target to Improve Cancer Immunotherapy

Medicine, Oncology, Life Sciences, Immunology,
tumor microenvironment   immunosuppression   platelet-activating factor   neutrophils   cancer immunotherapy  

The Potential Role of Platelet-Activating Factor in Cancer Immunotherapy Background Cancer immunotherapy has been a significant breakthrough in cancer treatment in recent years, but its efficacy is still limited by the immunosuppressive mechanisms within the tumor microenvironment (TME). The TME supports the differentiation and proliferation of mye...

Patient-Derived Acellular Ascites Fluid Affects Drug Responses in Ovarian Cancer Cell Lines Through the Activation of Key Signalling Pathways

Medicine, Obstetrics and Gynecology, Oncology, Life Sciences, Immunology,
ovarian cancer   acellular ascites fluid   drug sensitivity   signalling pathways   chemoresistance  

Impact of Patient-Derived Acellular Ascites on Drug Responses in Ovarian Cancer Cell Lines Through Activation of Key Signaling Pathways Background Ovarian cancer is one of the deadliest gynecological malignancies, with a 5-year survival rate of only 30% for patients with advanced epithelial ovarian cancer (EOC). Although surgery and chemotherapy (e...