Tumour Microenvironment-Mediated Drug Resistance in Neuroblastoma

Medicine, Pediatrics, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Neuroblastoma   Drug Resistance   Tumour Microenvironment   TGF-β1   Nuclear Factor-κB   Therapy  

Background Research Background: Both intrinsic and extrinsic factors in the tumor microenvironment (TME) can lead to treatment resistance. This paper reveals that the Transforming Growth Factor (TGF)-β1 produced within the TME increases drug resistance in neuroblastoma (NB) cells. Drug resistance is the main cause of cancer treatment failure, usual...

Effects of a Combined Exercise and Dietary Intervention on Body Composition, Physical Functioning, and Fatigue in Patients with Ovarian Cancer: Results of the Padova Trial

Effects of a Combined Exercise and Dietary Intervention on Body Composition, Physical Functioning, and Fatigue in Patients with Ovarian Cancer: Results of the Padova Trial

Medicine, Obstetrics and Gynecology, Sports Medicine, Oncology,
Ovarian Cancer   Body Composition   Physical Functioning   Fatigue   Exercise Intervention   Dietary Intervention   Randomized Controlled Trial  

Effects of Combined Exercise and Dietary Intervention on Body Composition, Physical Functioning, and Fatigue in Ovarian Cancer Patients: PADOVA Trial Results Academic Background Ovarian cancer is the seventh most common cancer among women, usually detected at an advanced stage, with an overall 5-year survival rate as low as 30-40%. Standard ovarian...

HLA-A+ Tertiary Lymphoid Structures with Reactivated Tumor-Infiltrating Lymphocytes Are Associated with a Positive Immunotherapy Response in Esophageal Squamous Cell Carcinoma

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
HLA-A+   Tertiary Lymphoid Structures   Esophageal Squamous Cell Carcinoma   Immunotherapy   Tumor-Infiltrating Lymphocytes   Antigen Presenting Machinery   Gene Expression  

In esophageal squamous cell carcinoma (ESCC), immune checkpoint blockade (ICB) therapy has achieved significant clinical benefits. However, the overall response rate to ICB treatment remains low. This study aims to identify biomarkers for ESCC response to ICB therapy and explore their potential clinical relevance. The authors of the paper come from...

Efficacy-Effectiveness Analysis on Survival in a Population-Based Real-World Study of BRAF-Mutated Metastatic Colorectal Cancer Patients Treated with Encorafenib-Cetuximab

Medicine, Basic Medical Sciences, Gastroenterology, Oncology, Life Sciences, Genetics,
BRAF mutation   metastatic colorectal cancer   Encorafenib   Cetuximab   real-world study   survival rate   efficacy  

Efficacy-Effectiveness Analysis of Encorafenib-Cetuximab Treatment in Patients with Oncogene-Mutated Metastatic Colorectal Cancer: A Cohort Study Research Background With the advancement of personalized medicine, targeted therapy has become an important means to treat various cancers. In metastatic colorectal cancer (mCRC), the combination of encor...

The Road to Tailored Adjuvant Chemotherapy for All Four Non-Pancreatic Periampullary Cancers: An International Multimethod Cohort Study

The Road to Tailored Adjuvant Chemotherapy for All Four Non-Pancreatic Periampullary Cancers: An International Multimethod Cohort Study

Medicine, Hepatobiliary System, Medical Laboratory Science, Oncology,
Non-Pancreatic Periampullary Cancer   Adjuvant Chemotherapy   Overall Survival   Long-term Outcome   Tailored Treatment  

The Path to Individualized Adjuvant Chemotherapy for All Four Types of Non-Pancreatic Periampullary Cancers: An International Multi-Method Cohort Study Background and Study Aim Although duodenal adenocarcinoma (DAC), intestinal type ampullary adenocarcinoma (AMPIT), pancreatobiliary type ampullary adenocarcinoma (AMPPB), and distal cholangiocarcino...

Menopausal Hormone Therapy and Breast Cancer Risk: A Population-Based Cohort Study of 1.3 Million Women in Norway

Medicine, Obstetrics and Gynecology, Geriatrics, Oncology,
Menopausal hormone therapy   Breast cancer risk   Population-based cohort study   Oral estrogen   Progestin   Body mass index   Molecular subtype  

Epidemiological Study on Menopausal Hormone Therapy and Breast Cancer Risk Introduction This study aims to explore the relationship between Menopausal Hormone Therapy (HT) and the risk of Breast Cancer (BC). While HT can relieve menopausal symptoms in women (such as hot flashes, fatigue, and urinary pain), it may also pose other health risks like a...