Clonal Hematopoiesis in Patients with Neuroendocrine Tumor Treated with Lutetium-177 and the Risk of Thrombocytopenia: A Prospective Study

Clonal Hematopoiesis in Patients with Neuroendocrine Tumor Treated with Lutetium-177 and the Risk of Thrombocytopenia: A Prospective Study

Medicine, Endocrinology, Hematology, Oncology,
clonal hematopoiesis   neuroendocrine tumor   thrombocytopenia   lutetium-177   radionuclide therapy   myeloid neoplasm   genetic mutations  

Clonal Hematopoiesis and Risk of Thrombocytopenia in Neuroendocrine Tumor Patients Undergoing 177Lu Therapy: A Prospective Study Background and Research Motivation The incidence of Neuroendocrine Tumors (NETs) has gradually increased in recent years. Prognosis depends on various factors such as the location of the primary tumor, disease grading, st...

Association of Timely Comprehensive Genomic Profiling with Precision Oncology Treatment Use and Patient Outcomes in Advanced Non-Small-Cell Lung Cancer

Association of Timely Comprehensive Genomic Profiling with Precision Oncology Treatment Use and Patient Outcomes in Advanced Non-Small-Cell Lung Cancer

Medicine, Respiratory System, Oncology,
non-small-cell lung cancer   genomic profiling   precision oncology   immune checkpoint inhibitors   survival rate   treatment selection  

Study on the Association Between the Timeliness of Comprehensive Genomic Profiling in Precision Oncology and Treatment Choices and Outcomes for Patients with Advanced Non-Small Cell Lung Cancer Introduction Advanced non-small-cell lung cancer (ANSCLC) is a highly lethal malignancy, and treatment choices directly affect the overall survival rate of ...

Circulating and Imaging Biomarkers of Radium-223 Response in Metastatic Castration-Resistant Prostate Cancer

Circulating and Imaging Biomarkers of Radium-223 Response in Metastatic Castration-Resistant Prostate Cancer

Medicine, Medical Laboratory Science, Urology, Medical Imaging, Oncology,
Radium-223   Castration-Resistant Prostate Cancer   Biomarkers   Bone Metastases   Circulating Tumor Cells   Automated Bone Scan Index  

Background of Urgent Problem Prostate cancer is one of the most common cancers among men. Metastatic castration-resistant prostate cancer (mCRPC) is an advanced form of prostate cancer characterized by resistance to castration therapy. Radium-223 is an α-emitting radiopharmaceutical that has been shown to improve overall survival (OS) and reduce sk...

Comprehensive Genomic Analysis of Patients with Non–Small-Cell Lung Cancer Using Blood-Based Circulating Tumor DNA Assay: Findings from the BFAST Database of a Single Center in Taiwan

Medicine, Medical Laboratory Science, Hematology, Oncology, Life Sciences, Immunology, Genetics,
Non-Small-Cell Lung Cancer   Blood Test   Circulating Tumor DNA   Genomic Analysis   BFAST   Actionable Mutations  

Latest Research in Lung Cancer Genomics: Analysis of Circulating Tumor DNA Detection in Non-Small Cell Lung Cancer Background and Motivation In recent years, the treatment of non-small cell lung cancer (NSCLC) has seen significant changes due to the success of targeted therapies. The National Comprehensive Cancer Network guidelines recommend extens...

Pan-Cancer Interrogation of MUTYH Variants Reveals Biallelic Inactivation and Defective Base Excision Repair Across a Spectrum of Solid Tumors

Medicine, Basic Medical Sciences, Oncology, Life Sciences, Biochemistry, Immunology, Genetics,
pan-cancer   MUTYH variants   biallelic inactivation   base excision repair   tumors  

Cross-Cancer Study Reveals Biallelic Inactivation of MUTYH and Base Excision Repair Defects in Different Types of Solid Tumors Research Background In daily life, cells are often exposed to endogenous and exogenous oxidative stress, originating from by-products of cellular respiration and various external compounds. MUTYH is a key component of the b...

Hereditary Cancer Screening and Outcomes at an Urban Safety-Net Hospital

Medicine, Medical Laboratory Science, Oncology, Life Sciences, Genetics,
Hereditary Cancer Syndromes   Genetic Testing   Cancer Risk   Urban Hospital   Ethnic Minorities   Disparities   Cancer Care  

Screening and Outcomes of Hereditary Cancer Syndromes: A Study at an Urban Safety Net Hospital Study Background Patients with Hereditary Cancer Syndromes (HCS) have a higher lifetime risk of developing cancer. Historically, underserved populations have lower rates of genetic evaluation. Hence, researchers aim to understand the demographic factors i...