Epithelial−Mesenchymal Transition Induced by Tumor Cell-Intrinsic PD-L1 Signaling Predicts a Poor Response to Immune Checkpoint Inhibitors in PD-L1-High Lung Cancer

Medicine, Rheumatology and Immunology, Respiratory System, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
PD-L1   Epithelial-Mesenchymal Transition   Non-Small-Cell Lung Cancer   Immune Checkpoint Inhibitors   Biomarkers   Tumor Progression  

Tumor Cell-Intrinsic PD-L1 Signaling Induces Epithelial-Mesenchymal Transition (EMT) Predicting Poor Response to Immune Checkpoint Inhibitors in PD-L1 High-Expressing Lung Cancer Research Background and Motivation In cancer immunotherapy, Programmed Death Ligand-1 (PD-L1) inhibits immune responses by binding to Programmed Death-1 (PD-1) receptors o...

Synergistic Antitumor Activity by Dual Blockade of CCR1 and CXCR2 Expressed on Myeloid Cells within the Tumor Microenvironment

Synergistic Antitumor Activity by Dual Blockade of CCR1 and CXCR2 Expressed on Myeloid Cells within the Tumor Microenvironment

Medicine, Medical Laboratory Science, Gastroenterology, Oncology, Life Sciences, Biochemistry, Immunology,
CCR1   CXCR2   Colorectal Cancer   Tumor Microenvironment   Dual Blockade   Myeloid Cells   Antitumor Activity  

Achieving Synergistic Antitumor Activity by Dual Blocking of CCR1 and CXCR2 Expression in Myeloid Cells Background Introduction Colorectal Cancer (CRC) poses a global health crisis, with its incidence and mortality rates rapidly rising in recent years. Over the past 15 years, the mortality rate of CRC has increased by more than 30%, and it is expec...

Hypoxia- and Postirradiation Reoxygenation-Induced HMHA1/ARHGAP45 Expression Contributes to Cancer Cell Invasion in a HIF-Dependent Manner

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
hypoxia   radiation   reoxygenation   cancer cell invasion   HIF-dependent   HMHA1   ARHGAP45  

Contribution of HMHA1/ARHGAP45 Expression Induced by Hypoxia and Post-Radiation Reoxygenation to Cancer Cell Invasion: An HIF-Dependent Mechanism Background and Motivation Prior studies have extensively demonstrated that cancer cells in solid tumors acquire malignant characteristics such as invasiveness and treatment resistance under hypoxic condit...

Genomic Profiling of Small Bowel Adenocarcinoma: A Pooled Analysis from 3 Databases

Medicine, Medical Laboratory Science, Gastroenterology, Oncology, Life Sciences, Biochemistry, Genetics,
small bowel adenocarcinoma   genomic profiling   mutations   prognosis   staging   prognostic factors   biomarkers  

Overview of Genomics in Small Bowel Adenocarcinoma: A Data Integration Analysis Based on Three Major Databases Background and Significance of the Study Small Bowel Adenocarcinoma (SBA) is a rare tumor, but its incidence has increased in recent years, especially in duodenal adenocarcinoma. Approximately 20% of SBA patients have certain susceptibilit...

Oncofetal SNRPE Promotes HCC Tumorigenesis by Regulating FGFR4 Expression through Alternative Splicing

Medicine, Hepatobiliary System, Oncology, Life Sciences, Cell Biology, Biochemistry,
SNRPE   Hepatocellular carcinoma   FGFR4   Alternative splicing   Tumor therapeutic target  

Study on the Key Role of Oncofetal snrpe in the Tumorigenesis and Progression of Hepatocellular Carcinoma Research Background and Purpose Hepatocellular carcinoma (HCC) is the sixth most prevalent cancer worldwide and the third leading cause of cancer-related deaths. However, due to the lack of understanding of key molecular events in tumors, effec...

Tumour Microenvironment-Mediated Drug Resistance in Neuroblastoma

Medicine, Pediatrics, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Neuroblastoma   Drug Resistance   Tumour Microenvironment   TGF-β1   Nuclear Factor-κB   Therapy  

Background Research Background: Both intrinsic and extrinsic factors in the tumor microenvironment (TME) can lead to treatment resistance. This paper reveals that the Transforming Growth Factor (TGF)-β1 produced within the TME increases drug resistance in neuroblastoma (NB) cells. Drug resistance is the main cause of cancer treatment failure, usual...