Phosphocreatine Promotes Epigenetic Reprogramming to Facilitate Glioblastoma Growth through Stabilizing BRD2

Medicine, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry,
Phosphocreatine   Glioblastoma   Epigenetic   BRD2   Growth Promotion  

The research results, completed in collaboration by many scientists including Lishu Chen, Qinghui Qi, and Xiaoqing Jiang, were published in the groundbreaking journal Cancer Discovery. The report detailed how phosphocreatine (PCr) promotes the growth of glioblastoma (GBM) by stabilizing bromodomain-containing protein 2 (BRD2). This discovery provid...

CHD2 Regulates Neuron-Glioma Interactions in Pediatric Glioma

Medicine, Basic Medical Sciences, Neurology, Oncology, Life Sciences, Biochemistry, Genetics,
CHD2   glioma   pediatric   neuron interactions   histone mutation   epigenetic regulation  

Research Report on the Regulation of Neuron-Glioma Interactions by CHD2 in Pediatric Gliomas Background High-grade gliomas (HGG) are fatal diseases in both adult and pediatric patients. Recent studies have shown that neuronal activity can promote the progression of various high-grade glioma subgroups. However, the epigenetic mechanisms regulating t...

Study of Lifileucel, an Autologous Tumor-Infiltrating Lymphocyte Monotherapy, in Patients with Advanced Non–Small Cell Lung Cancer Resistant to Immune Checkpoint Inhibitors

Study of Lifileucel, an Autologous Tumor-Infiltrating Lymphocyte Monotherapy, in Patients with Advanced Non–Small Cell Lung Cancer Resistant to Immune Checkpoint Inhibitors

Medicine, Respiratory System, Oncology, Life Sciences, Immunology,
Autologous Tumor-Infiltrating Lymphocyte   Advanced Non–Small Cell Lung Cancer   Immune Checkpoint Inhibitors   Monotherapy   Treatment Efficacy  

Application of Lifileucel in Advanced Non-Small Cell Lung Cancer Patients Resistant to Immune Checkpoint Inhibitors This article, authored by Adam J. Schoenfeld and numerous other top scholars, was published in the 2024 edition of Cancer Discovery. The study is based on a multi-center phase II clinical trial aiming to evaluate the efficacy and safe...

D3S-001: A KRAS G12C Inhibitor with Rapid Target Engagement Kinetics, Overcomes Nucleotide Cycling, and Demonstrates Robust Preclinical and Clinical Activities

Medicine, Basic Medical Sciences, Oncology,
D3S-001   KRAS G12C   inhibitor   nucleotide cycling   clinical activity   antitumor activity  

D3S-001, a KRAS G12C Inhibitor with Rapid Target Engagement Kinetics, Inhibits Nucleotide Cycling and Demonstrates Robust Preclinical and Clinical Activity Background Introduction The KRAS (Kirsten rat sarcoma viral oncogene homolog) gene mutation is one of the oncogenic drivers in various solid tumors (such as non-small cell lung cancer (NSCLC) an...

St. Jude Survivorship Portal: Sharing and Analyzing Large Clinical and Genomic Datasets from Pediatric Cancer Survivors

St. Jude Survivorship Portal: Sharing and Analyzing Large Clinical and Genomic Datasets from Pediatric Cancer Survivors

Information Science, Computer Science, Medicine, Pediatrics, Medical Laboratory Science, Oncology, Cardiovascular System, Life Sciences, Biochemistry, Immunology, Genetics,
St. Jude   survivorship   data portal   pediatric cancer   clinical data   genomic data  

St. Jude Survivorship Portal: Analysis and Sharing of Large-Scale Clinical and Genomic Data of Pediatric Cancer Survivors Research Background In the United States, the five-year survival rate for childhood cancer has increased from about 60% in the 1970s to over 85% today. Despite the significant improvement in survival rates, these childhood cance...

Identification of Clonal Hematopoiesis Driver Mutations Through In Silico Saturation Mutagenesis

Information Science, Computer Science, Artificial Intelligence, Medicine, Basic Medical Sciences, Hematology, Oncology, Life Sciences, Immunology, Genetics,
clonal hematopoiesis   driver mutations   in silico saturation mutagenesis   machine learning models   oncology  

Introduction In the process of healthy hematopoiesis, a group of hematopoietic stem cells (HSC) contribute to all blood-related lineages. However, as we age, this process often leads to clonal hematopoiesis (CH), meaning the expansion of clones originating from a particular HSC, which then occupies a significant portion of blood cells and platelets...