Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection

Medicine, Respiratory System, Medical Laboratory Science, Medical Imaging, Oncology, Life Sciences, Immunology,
cell-free DNA   lung cancer   early detection   fragmentome   machine learning  

Clinical Validation Study on the Application of Cell-Free DNA Fragment Analysis in Enhancing Early Detection of Lung Cancer Background Lung cancer is one of the leading types of cancer threatening the health of both men and women globally. Over 125,000 people die from lung cancer in the United States each year, and globally, the number is close to ...

Targeting Acute Myeloid Leukemia Stem Cells Through Perturbation of Mitochondrial Calcium

Targeting Acute Myeloid Leukemia Stem Cells Through Perturbation of Mitochondrial Calcium

Medicine, Basic Medical Sciences, Hematology, Oncology, Life Sciences, Cell Biology, Biochemistry,
Acute Myeloid Leukemia   Stem Cells   Mitochondrial Calcium   Oxidative Phosphorylation   Drug Resistance  

This is an academic paper report on the study of acute myeloid leukemia (AML) stem cells. The study found that venetoclax treatment targeting the BCL-2 protein induces different mitochondrial calcium signaling changes in drug-sensitive and drug-resistant AML stem cells, thereby affecting their oxidative phosphorylation metabolism and survival. The ...

Mechanisms of Response and Tolerance to Active RAS Inhibition in KRAS-Mutant NSCLC

Medicine, Basic Medical Sciences, Oncology, Life Sciences, Cell Biology, Biochemistry,
KRAS   mutations   NSCLC   active RAS inhibition   drug-tolerant persisters  

Response and Resistance Mechanisms of RAS Inhibitors in KRAS-Mutant NSCLC Research Background With the clinical development of RAS inhibitors, the treatment of KRAS-mutant Non-Small Cell Lung Cancer (NSCLC) faces a new turning point. However, in clinical practice, patients show poor long-term responses to RAS inhibitors, influencing clinical effica...

Clonal Lineage Tracing with Recordable Barcodes Reveals Migration Histories of Metastatic Prostate Cancer

Medicine, Geriatrics, Urology, Oncology,
clonal lineage tracing   metastatic prostate cancer   barcodes   tumor evolution   mouse model   tumor heterogeneity  

title: “Utilizing Clonal Lineage Tracing with Recordable Barcodes Unveils the Migration History of Prostate Cancer Metastasis” author: Ryan N. Serio, Armin Scheben, *Billy Lu, *Domenic V. Gargiulo, Lucrezia Patruno, Caroline L. Buckholtz, Ryan J. Chaffee, Megan C. Jibilian, Steven G. Persaud, Stephen J. Staklinski, Rebecca Hassett, Lise M. Brault, ...

Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors

Medicine, Respiratory System, Oncology, Life Sciences, Biochemistry, Genetics,
MET   kinase domain   point mutation   lung cancer   malignancies   targeted therapy  

This study reveals a new targetable cancer subtype characterized by activating point mutations in the MET tyrosine kinase domain (TKD). Researchers identified MET TKD activating mutations in approximately 0.5% of patients across a genomic data set of over 600,000 cancer cases, encompassing various tumor types, with the highest prevalence in renal c...

Iron-(Fe3+)-Dependent Reactivation of Telomerase Drives Colorectal Cancers

Iron-(Fe3+)-Dependent Reactivation of Telomerase Drives Colorectal Cancers

Medicine, Gastroenterology, Oncology, Life Sciences, Biochemistry, Genetics,
iron   telomerase   colorectal cancer   reactivation   red meat   cancer mechanism   drug target  

Iron (Ferric Ion, Fe3+)-Dependent Telomerase Reactivation Drives Colorectal Cancer Development I. Research Background Colorectal Cancer (CRC) is the third most common cancer globally, involving both genetic and non-genetic factors in its pathogenesis. Existing research shows a significant association between high iron content, hereditary iron overl...