Research on Choroid Plexus Aging and Cerebrospinal Fluid Dynamics Background Introduction The choroid plexus (CHP) is a highly vascularized structure located within the brain ventricles, primarily responsible for the production of cerebrospinal fluid (CSF) and the clearance of metabolic waste. It plays a crucial role in maintaining neurofluid homeo...
Numerical Simulation Study of Cerebrospinal Fluid Drainage through Cervical Lymphatic Vessels Background Introduction Cerebrospinal fluid (CSF) is a clear fluid that circulates around the brain and spinal cord, providing physical protection, nutrient supply, and waste clearance for the central nervous system. In recent years, growing evidence sugge...
Application of Automated In Vitro Models in Hydrocephalus Research Background Introduction Hydrocephalus is a neurological condition caused by the accumulation of cerebrospinal fluid (CSF) in the brain’s ventricles. If left untreated, it can lead to severe complications and permanent brain damage. It is estimated that 1 in every 500 newborns is bor...
Study on Cerebrospinal Fluid Flow Dynamics and Its Application in Drug Delivery Background Introduction Cerebrospinal fluid (CSF) plays a crucial role in the human spinal canal, responsible for transporting dissolved nutrients and waste products. Due to its pulsatile nature, CSF flow is influenced by cardiac and respiratory cycles. In recent years,...
Association Between Choroid Plexus Volume and Cognitive Function in Community-Dwelling Older Adults: A Research Study Academic Background With the increasing global aging population, the number of dementia patients is rising annually. Early identification of older adults with declining cognitive function and guiding them toward preventive and thera...
Assessment of Brain Endothelial Permeability, Transport, and Flow Background Introduction The blood-brain barrier (BBB) is a critical barrier that protects the brain from harmful substances while also serving as a key obstacle for drug delivery to the brain. The permeability and transport properties of the BBB directly influence the distribution of...
The Role of Nrf2 in Maintaining the Integrity of the Blood-Brain Barrier Academic Background The blood-brain barrier (BBB) is a crucial barrier between the central nervous system (CNS) and the peripheral blood circulation, composed of endothelial cells, pericytes, smooth muscle cells, astrocytes, and neurons. The primary function of the BBB is to s...
Non-invasive MRI Study of Blood-Cerebrospinal Fluid Barrier Function in a Mouse Model of Alzheimer’s Disease Academic Background Alzheimer’s Disease (AD) is a common neurodegenerative disorder characterized by the accumulation of β-amyloid (Aβ) plaques and neurofibrillary tangles. Recent studies have increasingly shown that the Blood-Cerebrospinal ...
Study on the Interaction Between Cerebral Blood Flow and Cerebrospinal Fluid Dynamics Measured at Intracranial and Extracranial Planes Background The interaction between cerebral blood flow (CBF) and cerebrospinal fluid (CSF) is a critical factor in maintaining intracranial pressure (ICP) stability. According to the Monro-Kellie doctrine, the intra...
The Impact of Inflammation on Brain Delivery of Oxycodone Academic Background Oxycodone is a widely used opioid analgesic with a unique property of being actively transported from the blood to the brain across the blood-brain barrier (BBB). This process is believed to be associated with the proton-coupled organic cation (H+/OC) antiporter system. H...