Artificial Dynamic Structure Ensemble-Guided Rational Design of a Universal RNA Aptamer–Based Sensing Tag

Life Sciences, Biochemistry, Bioengineering, Genetics, Biophysics,
Artificial RNA   Dynamic Structure Ensemble   Fluorogenic RNA Aptamer   Biosensing   Gene Editing  

Artificial Dynamic RNA Structure Ensemble-Guided Rational Design of a Universal RNA Aptamer-Based Sensing Tag Academic Background RNA molecules play versatile roles in both natural and synthetic biological systems, with their functions strongly dependent on their dynamic and specific three-dimensional structures. RNA secondary and tertiary structur...

Toward Optimal Disease Surveillance with Graph-Based Active Learning

Mathematics, Information Science, Medicine, Environmental and Public Health,
disease surveillance   active learning   network dynamics   epidemiology   public health  

Toward Optimal Disease Surveillance with Graph-Based Active Learning Academic Background With the acceleration of globalization, the speed and scope of infectious disease transmission have significantly increased. How to effectively monitor and control the spread of infectious diseases has become a critical issue in public health. Traditional disea...

Mantle Oxidation by Sulfur Drives the Formation of Giant Gold Deposits in Subduction Zones

Earth Sciences, Geochemistry, Engineering, Mining and Metallurgical Engineering,
sulfur oxidation   subduction zone   gold deposits   mantle wedge   sulfur ligand  

Mantle Oxidation by Sulfur Drives the Formation of Giant Gold Deposits in Subduction Zones Academic Background Most of Earth’s metal resources are concentrated in magmatic arc environments, and subduction zones are the primary regions for mass exchange between the mantle and crust. Fluids released from subducting slabs are believed to oxidize the o...

Parallel Mechanical Computing: Metamaterials That Can Multitask

Materials Science, Information Science, Computer Science,
parallel computing   metamaterials   mechanical computing   frequency multiplexing   wave-based computing  

Parallel Mechanical Computing: Metamaterials That Can Multitask Academic Background Decades after being replaced by digital computing platforms, analog computing has regained significant interest due to advancements in metamaterials and intricate fabrication techniques. Particularly, wave-based analog computers, which perform spatial transformation...

Engineering Bacteria for Cancer Immunotherapy by Inhibiting IDO Activity and Reprogramming CD8+ T Cell Response

Medicine, Oncology, Life Sciences, Cell Biology, Bioengineering, Immunology, Microbiology,
engineered bacteria   IDO inhibitors   CD8+ T cells   cancer immunotherapy   synthetic biology  

Synthetic Biology in Cancer Immunotherapy: Engineering Bacteria to Inhibit IDO Activity and Reprogram CD8+ T Cell Responses Academic Background In recent years, significant progress has been made in cancer immunotherapy, particularly through the activation of T cells to combat tumors. However, metabolic adaptations in the tumor microenvironment (TM...

Little Evidence That Nonmonogamous Family Structures Are Detrimental to Children’s Well-Being in Mpimbwe, Tanzania

Humanities and Others,
family structure   child well-being   Tanzania   polygyny   longitudinal study  

Report on the Academic Paper: “Little Evidence That Nonmonogamous Family Structures Are Detrimental to Children’s Well-Being in Mpimbwe, Tanzania” Academic Background In traditional Western perspectives, nuclear family structures (comprising parents and children) are often considered the cornerstone of children’s well-being. Non-nuclear family stru...

Cyanobacteria–Probiotics Symbionts for Modulation of Intestinal Inflammation and Microbiome Dysregulation in Colitis

Medicine, Gastroenterology, Life Sciences, Microbiology,
Inflammatory Bowel Disease   Cyanobacteria   Probiotics   Hydrogen Gas   Gut Microbiota  

Cyanobacteria–Probiotics Symbionts for Modulation of Intestinal Inflammation and Microbiome Dysregulation in Colitis Academic Background Inflammatory Bowel Disease (IBD) is a group of chronic inflammatory conditions of the gut, primarily including Crohn’s Disease (CD) and Ulcerative Colitis (UC). The pathogenesis of IBD is complex, involving dysfun...

Nutrient Colimitation as a Quantitative, Dynamic Property of Microbial Populations

Life Sciences, Microbiology,
microbial growth   nutrient limitation   colimitation   biogeochemistry   Escherichia coli  

Quantitative and Dynamic Properties of Nutrient Colimitation in Microbial Populations Academic Background The growth, physiology, and metabolic activity of microorganisms are fundamentally controlled by resource availability. Understanding which resources limit microbial growth and to what extent is not only a core concept in microbiology but also ...

Transport and Energetics of Bacterial Rectification

Life Sciences, Microbiology,
bacterial rectification   active matter   nonequilibrium processes   entropy production   work extraction  

Transport and Energetics of Bacterial Rectification Academic Background In nature, many biological systems rely on the directed motion of microscopic particles to achieve their functions. For example, the unidirectional movement of molecular motors (such as kinesins) along microtubules is crucial for intracellular transport. However, the mechanisms...

Synthesis of Evidence Yields High Social Cost of Carbon Due to Structural Model Variation and Uncertainties

Humanities and Others,
Social Cost of Carbon   Structural Model   Uncertainty   Climate Change   Environmental Economics  

Synthesis of Evidence Yields High Social Cost of Carbon Due to Structural Model Variation and Uncertainties Academic Background Climate change is one of the most severe challenges facing the world today, with profound impacts on the economy, society, and the environment. To quantify the economic costs of climate change, the academic community has p...