Spin-Symmetry-Enforced Solution of the Many-Body Schrödinger Equation with a Deep Neural Network

Research on Deep Learning Framework for Spin-Symmetry-Enforced Solutions to the Many-Body Schrödinger Equation: A Groundbreaking Achievement In the fields of quantum physics and quantum chemistry, the description of many-body electron systems has always been an important yet highly challenging topic. Accurately characterizing strong electron-electr...

Predicting Crystals Formation from Amorphous Precursors Using Deep Learning Potentials

Predicting the Emergence of Crystals from Amorphous Precursors: Deep Learning Empowers Breakthroughs in Materials Science Background Introduction The process of crystallization from amorphous materials holds significant importance in both natural and laboratory settings. This phenomenon is widespread in various processes ranging from geological to ...

Glepaglutide-Loaded Foam for Inducing Mucosal Healing in Inflammatory Bowel Disease Treatment

A Novel Rectal Foam Formulation for the Treatment of Inflammatory Bowel Disease In recent years, the incidence of inflammatory bowel disease (IBD), characterized by mucosal damage, chronic inflammation, and recurrent episodes, has been steadily rising, yet ideal therapeutic solutions remain elusive. Researchers have identified a 33-amino acid pepti...

Kidney Fibrosis in In Vitro and In Vivo Models: Path Toward Physiologically Relevant Humanized Models

Mechanisms and Research Models of Kidney Fibrosis: Progress Toward Physiologically Relevant Humanized Models Research Background and Problem Statement Chronic Kidney Disease (CKD) is a major global public health issue, estimated to affect more than 10% of the population and is one of the leading causes of mortality. Kidney fibrosis, as a key pathol...

Efficacy and Cellular Mechanism of Biomimetic Marine Adhesive Protein-Based Coating Against Skin Photoaging

Research Advances on the Use of Biomimetic Marine Adhesive Protein Coating for Skin Photoaging Prevention Skin photoaging is a significant global health issue, particularly for individuals exposed to prolonged ultraviolet (UV) radiation in outdoor environments. Its manifestations include a reduction in collagen, increased wrinkles, loss of skin ela...

Macrophage Membrane-Camouflaged Nanozymes for Combating Oxidative Stress-Microvascular Perfusion Negative Feedback in Ischemia-Reperfusion Induced Acute Kidney Injury

Innovative Research Report on Intravenous Macrophage Membrane-Camouflaged Nanozymes for Acute Kidney Injury Targeted Therapy Background Introduction Acute kidney injury (AKI) is a severe clinical syndrome characterized by a rapid decline in renal function and is closely associated with high morbidity and mortality. Statistics show that the incidenc...

Next-Generation Oral Ulcer Management: Integrating Cold Atmospheric Plasma (CAP) with Nanogel-Based Pharmaceuticals for Inflammation Regulation

Breakthrough in Next-Generation Oral Ulcer Management: Integration of Cold Plasma and Nanogel Pharmaceutical Systems Background Oral ulcers are one of the most common mucosal diseases, significantly affecting patients’ quality of life. According to epidemiological data, approximately 27.9% of adults suffer from oral ulcers. While these lesions ofte...

Facile Fabrication of Injectable Multifunctional Hydrogels Based on Gallium-Polyphenol Networks with Superior Antibacterial Activity for Promoting Infected Wound Healing

A Novel Study on Multifunctional Hydrogels for Promoting Infected Wound Healing In the current clinical setting, infected wounds, especially those caused by antibiotic-resistant pathogens, have become a major challenge. These chronic or hard-to-heal wounds often suffer from delayed healing processes due to excessive inflammation, bacterial biofilm ...

A Potential 3-in-1 Combined Anti-SARS-CoV-2 Therapy Using Pulmonary MIL-100(Fe) Formulation

Exploration of a Novel Pulmonary Anti-SARS-CoV-2 Therapy Based on MIL-100(Fe) In recent years, global public health has faced numerous severe challenges, particularly since 2019 with the outbreak of the SARS-CoV-2 coronavirus pandemic. The high transmission rate and persistence of the virus have exposed bottlenecks in current prevention and treatme...

A Dual-Pipeline Lactate Removal Strategy to Reverse Vascular Hyperpermeability for the Management of Lipopolysaccharide-Induced Sepsis

A Novel Dual-Pipeline Lactate Removal Strategy for Sepsis Treatment Background Sepsis, defined as multi-organ dysfunction caused by a dysregulated host immune response to bloodborne infection, remains a severe global public health issue. Despite advances in modern medicine, the diagnosis and treatment of sepsis pose significant challenges. Statisti...