Real-world Assessment of Patient Characteristics, Clinical Features, Treatment Patterns, and Outcomes Associated with Erythropoietic Protoporphyria and X-linked Protoporphyria Academic Background Erythropoietic Protoporphyria (EPP) and X-linked Protoporphyria (XLP) are two rare inherited metabolic disorders. The prevalence of EPP varies across coun...

Characteristics of Suitable Cases for Nemolizumab Treatment Based on Clinical Findings and Cutaneous Adverse Events Academic Background Atopic Dermatitis (AD) is a common chronic inflammatory skin disease, characterized by intense itching that significantly impacts patients’ quality of life. In recent years, treatment methods for AD have advanced, ...

Stochastic Modeling of Single-Cell Gene Expression Adaptation Reveals Non-Genomic Contribution to Tumor Subclone Evolution Academic Background Cancer is a complex disease whose progression is driven by the evolution of cells that are selected through adaptive advantages for growth. Traditionally, cancer evolution research has focused primarily on g...

New Breakthrough in T Cell Receptor (TCR) Specificity Prediction: The Introduction of the SCEPTR Model Academic Background T cell receptors (TCRs) play a crucial role in the immune system by determining the specificity of immune responses through their binding to peptide-MHC complexes (pMHCs). Understanding the interaction between TCRs and specific...

CDK2 Activity Interference on ERK and p38 KTR Signals and Computational Correction Methods Recently, a paper published in Cell Systems by authors Timothy E. Hoffman, Chengzhe Tian, Varuna Nangia, and others revealed the interference of cyclin-dependent kinase 2 (CDK2) on the kinase translocation reporter (KTR) signals in the extracellular signal-re...

Modular Brain-Machine Interface: Innovative Breakthrough in Neurorecording, Neurostimulation, and Drug Delivery Academic Background Brain-Machine Interfaces (BMIs) are crucial tools in neuroscience and clinical medicine, enabling interactions between the brain and the external world through charge, matter, and information exchange. They are widely ...

Academic Background With the rapid development of the Metaverse, human-machine interface (HMI) technology has become a key link between virtual space and human users. Among these, gesture recognition technology is particularly important in the Metaverse, especially the precise capture of finger movements. Traditional bending sensors used for gestur...

Improving Glioblastoma Treatment with Imaging, Radiotherapy, Drug Delivery, and Therapeutic Systems Academic Background Glioblastoma (GBM) is the most common and aggressive type of brain cancer, with an extremely poor prognosis and a five-year survival rate of less than 10%. Despite decades of extensive research in drug therapy, radiation therapy, ...

Academic Background With the rapid development of artificial intelligence (AI), the role of electronic devices in modern life has become increasingly important. However, these devices generate a significant amount of heat during operation, and if not managed effectively, this can lead to performance degradation, shortened lifespan, and even system ...

Research on an Ultra-Low Power Carbon Dioxide Sensor for Real-Time Breath Monitoring Academic Background Carbon dioxide (CO₂) is a critical gas produced during human respiration, and its real-time monitoring is essential for diagnosing and treating respiratory diseases (e.g., asthma, dyspnea, sleep apnea) as well as metabolic disorders. Traditional...