Prevalence and Incidence of Comorbidities in Japanese Patients with Dermatologic Diseases Academic Background Dermatologic diseases such as atopic dermatitis (AD), psoriasis, alopecia areata (AA), and vitiligo are common chronic inflammatory or autoimmune skin disorders. These conditions not only significantly impact patients’ quality of life but a...

Predominant Infiltration of M2a Macrophages in Genital Verruciform Xanthoma Academic Background Verruciform xanthoma (VX) is a rare benign verrucous tumor first reported by Sachs in 1903 and formally named by Shafer in 1971. This lesion primarily occurs in the genital area and oral mucosa of elderly individuals. Histopathologically, it is character...

A Report on the Validation of the Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) Score and the Establishment of a Novel Score (J-LRINEC) in Japanese Patients Academic Background Necrotizing fasciitis (NF) and cellulitis are two common skin infectious diseases. Although they share some similarities in clinical manifestations, their sev...

The Impact of Antibiotic Therapy on Psoriasis Patients with Streptococcal Infection Academic Background Psoriasis is a chronic, relapsing inflammatory systemic skin disease with a global prevalence of around 2%-3%. Although its pathogenesis is not fully understood, studies suggest that bacterial, viral, and fungal infections may induce or exacerbat...

Academic Background Pemphigus Vulgaris (PV) is a rare and severe autoimmune blistering disease characterized by a chronic course accompanied by multiple complications and side effects from medication. Currently, guidelines in many countries recognize systemic corticosteroids (CS) and rituximab (RTX) as first-line treatments for PV. However, due to ...

Research Background Recessive dystrophic epidermolysis bullosa (RDEB) is a rare genetic skin disorder caused by mutations in the COL7A1 gene, leading to the absence or dysfunction of type VII collagen (C7). Type VII collagen is a crucial protein for maintaining skin structural stability, and its deficiency makes patients’ skin extremely fragile, pr...

Predictive Factors for Treatment Responses to Baricitinib in Severe Alopecia Areata: A Retrospective Multivariate Analysis Academic Background Alopecia Areata (AA) is a chronic autoimmune skin disease characterized by non-scarring hair loss. Its pathogenesis involves an abnormal immune attack on hair follicles, leading to hair loss. In recent years...

Clinical Characteristics and Possible Mechanisms of Age Differences in Bullous Pemphigoid (BP) Patients Academic Background Bullous Pemphigoid (BP) is an acquired autoimmune blistering disease that primarily affects elderly patients. However, in recent years, the incidence of BP among younger individuals has also increased, with younger patients of...

Biomarkers Associated with the Progression of Infantile Hemangioma: An Exploratory Study Academic Background Infantile Hemangioma (IH) is one of the most common benign tumors in infancy. Although most IH is not apparent at birth, it gradually manifests within the first month of life and undergoes a proliferative phase over approximately one year, f...

Real-World 52-Week Effectiveness Study of Deucravacitinib in Psoriasis Background Introduction Psoriasis is a chronic inflammatory skin disease with a global prevalence of approximately 1% to 3%. This condition not only affects patients’ quality of life (QoL) but is also often accompanied by comorbidities such as cardiovascular diseases, diabetes, ...