Moscatilin Inhibits Vascular Calcification by Activating IL13RA2-dependent Inhibition of STAT3 and Attenuating the Wnt3/β-catenin Signaling Pathway Background Vascular calcification is a pathological process involving the deposition of hydroxyapatite in the vessel wall, often associated with atherosclerotic cardiovascular disease and chronic kidney...

DNA Hypomethylation-Mediated Upregulation of GADD45B Facilitates Airway Inflammation and Epithelial Cell Senescence in COPD Academic Background Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous disease characterized by chronic airway inflammation and irreversible airflow limitation, and it is one of the leading causes of death worldwi...

Single-Cell Transcriptomics Reveals the Relationship Between Cardiac Fibroblasts and Angiogenesis: The Key Role of ANGPTL4 in HFpEF Background Introduction Heart failure is one of the major global health challenges today. Heart failure is categorized into heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection...

Academic Background Pathological Myocardial Hypertrophy (PMH) is an adaptive response of the heart under various pathological stimuli, but its long-term development ultimately leads to Heart Failure (HF). Although some understanding of the pathogenesis of PMH has been established, its mortality rate remains high, and there is an urgent need for new...

5-HT7R Enhances Neuroimmune Resilience and Alleviates Meningitis by Promoting CCR5 Ubiquitination Academic Background Bacterial meningitis is a rapidly onset, highly fatal disease with epidemic potential, especially when caused by Streptococcus pneumoniae (S.p.) infection. The destruction of the blood-brain barrier (BBB) leads to the release of inf...

HNRNPR-Mediated UPF3B mRNA Splicing Drives Hepatocellular Carcinoma Metastasis In recent years, hepatocellular carcinoma (HCC) has become one of the leading causes of cancer-related deaths worldwide due to its highly invasive and metastatic nature. The mechanisms underlying HCC metastasis are complex, with abnormal alternative splicing (AS) playing...

High-Performance SERS Detection of Dye Contaminants Using Novel Functionalized Carbon Dots Academic Background Dye molecules play a vital role in daily life, but the environmental pollution caused by their use cannot be ignored. Among them, Malachite Green (MG) is a triphenylmethane dye with potential carcinogenic, teratogenic, and mutagenic effect...

Collecting Duct NCOR1 Regulates Blood Pressure by Controlling Mineralocorticoid Receptor Academic Background Hypertension is one of the major risk factors for cardiovascular and cerebrovascular diseases globally, with complex and not fully elucidated mechanisms. The kidney plays a critical role in blood pressure regulation, particularly in the proc...

Metformin Enhances Plant Immunity by Blocking BIK1-Mediated CPK28 Phosphorylation Academic Background In the context of the increasingly severe global food security issues, controlling crop diseases has become a major challenge in agricultural production. Although traditional chemical pesticides can effectively control diseases, the environmental p...

Metal-Free Production of Natural Blue Colorants: Novel Insights from Anthocyanin-Protein Interactions Academic Background With increasing consumer awareness of health and natural food ingredients, the demand for natural colorants has been on the rise. However, natural blue colorants are scarce, and their production poses significant challenges. Cur...