Analysis of HER2 Expression Changes from Breast Primary to Brain Metastases and the Impact of HER2-Low Expression on Overall Survival

Medicine, Neurosurgery, Oncology,
breast cancer   brain metastases   HER2 expression   survival analysis   noninvasive diagnostics  

HER2 Expression Dynamics in Breast Cancer Brain Metastases and Its Impact on Survival Background Breast cancer is one of the most common cancers among women worldwide, and brain metastases (BrMs) pose a significant challenge for patients. In recent years, with the prolonged survival of breast cancer patients, the incidence of brain metastases has g...

Contemporary Prognostic Signatures and Refined Risk Stratification of Gliomas: An Analysis of 4400 Tumors

Medicine, Neurology, Neurosurgery, Oncology,
glioma   molecular classification   survival rate   risk stratification   genomic diversity   prognostic features   molecular markers  

Molecular Classification and Prognostic Features of Gliomas Background Introduction Glioma is the most common malignant brain tumor in adults, and its classification, risk stratification, and treatment standards have undergone significant changes in recent years. With the introduction of molecular markers, the classification system for gliomas has ...

Multimodal Deep Learning Improves Recurrence Risk Prediction in Pediatric Low-Grade Gliomas

Information Science, Artificial Intelligence, Medicine, Neurology, Medical Imaging, Oncology,
pediatric low-grade gliomas   deep learning   postoperative recurrence prediction   multimodal model   magnetic resonance imaging   risk stratification   survival analysis  

Application of Deep Learning in Postoperative Recurrence Prediction for Pediatric Low-Grade Gliomas Background Pediatric Low-Grade Gliomas (PLGGs) are one of the most common types of brain tumors in children, accounting for 30%-50% of all central nervous system tumors in children. Although the prognosis of PLGGs is relatively favorable, the risk of...

MYC-Dependent Upregulation of the De Novo Serine and Glycine Synthesis Pathway is a Targetable Metabolic Vulnerability in Group 3 Medulloblastoma

Medicine, Neurology, Neurosurgery, Oncology,
medulloblastoma   MYC amplification   metabolic vulnerability   serine synthesis   glycine synthesis   PHGDH inhibition   therapeutic strategy  

Targeting the Serine/Glycine Synthesis Pathway in MYC-Driven Medulloblastoma Background Medulloblastoma is one of the most common malignant brain tumors in children, accounting for a significant proportion of childhood cancer deaths. Based on molecular characteristics, medulloblastoma is classified into four major subgroups: WNT, SHH, Group 3 (MBGr...

Mapping Tumor Habitats in Isocitrate Dehydrogenase-Wild Type Glioblastoma: Integrating MRI, Pathologic, and RNA Data

Medicine, Neurology, Medical Imaging, Oncology,
glioblastoma   tumor habitats   MRI   pathology   RNA sequencing   spatial heterogeneity   IDH-wild type  

Pathological Validation of MRI Tumor Habitats in Glioblastoma Background Introduction Glioblastoma (GBM) is a highly malignant brain tumor characterized by significant heterogeneity and invasiveness. Due to its complex tumor microenvironment (TME), traditional imaging methods struggle to accurately distinguish different tumor regions, such as the t...

Long-term Outcome of the Milano-Hyperfractionated Accelerated Radiotherapy Strategy for High-Risk Medulloblastoma, Including the Impact of Molecular Subtype

Medicine, Neurology, Neurosurgery, Oncology,
high-risk medulloblastoma   hyperfractionated accelerated radiotherapy   molecular subtype   chemotherapy response   long-term survival  

Long-Term Outcomes of High-Risk Medulloblastoma Treatment Background Medulloblastoma is one of the most common malignant brain tumors in children. Despite advancements in treatment, the prognosis for high-risk medulloblastoma patients remains poor. High-risk medulloblastoma typically includes patients with metastatic disease, TP53 mutations, MYC/MY...