A TBX2-Driven Signaling Switch from Androgen Receptor to Glucocorticoid Receptor Confers Therapeutic Resistance in Prostate Cancer

Medicine, Urology, Endocrinology, Oncology,
prostate cancer   therapeutic resistance   TBX2   androgen receptor   glucocorticoid receptor   signaling switch   SP2509  

Academic Background and Problem Statement Prostate Cancer (PCA) is one of the most common malignancies in men, particularly in advanced stages, where patients typically receive Androgen Deprivation Therapy (ADT) as the standard treatment. However, despite initial treatment efficacy, patients eventually develop Castration-Resistant Prostate Cancer (...

PRMT5-Regulated Splicing of DNA Repair Genes Drives Chemoresistance in Breast Cancer Stem Cells

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
Breast Cancer Stem Cells   Chemoresistance   PRMT5   DNA Repair   Splicing Regulation   Homologous Recombination   Fanconi Anemia Pathway  

PRMT5-Regulated Splicing of DNA Repair Genes Drives Chemoresistance in Breast Cancer Stem Cells Academic Background Breast Cancer Stem Cells (BCSCs) are a rare subpopulation of cells within breast cancer that possess the ability to self-renew, initiate tumors, and metastasize. Despite their critical role in tumor initiation and progression, the mec...

Identification of Novel Germline Mutations in FUT7 and EXT1 Linked with Hereditary Multiple Exostoses

Medicine, Orthopedics, Oncology, Life Sciences, Genetics,
Hereditary Multiple Exostoses   FUT7   EXT1   germline mutations   chondrodysplasia   IL6/STAT3/Slug axis   ubiquitination degradation  

Novel Germline Mutations in FUT7 and EXT1 Linked to Hereditary Multiple Exostoses Background Hereditary Multiple Exostoses (HME), also known as Hereditary Multiple Osteochondromas (HMO), is an autosomal dominant skeletal disorder characterized by the development of multiple cartilage-capped bone projections (osteochondromas). These osteochondromas ...

Mitochondrial Unfolded Protein Response-Dependent β-Catenin Signaling Promotes Neuroendocrine Prostate Cancer

Medicine, Urology, Oncology, Life Sciences, Cell Biology, Biochemistry,
Mitochondrial Unfolded Protein Response   β-Catenin   Neuroendocrine Prostate Cancer   Heat Shock Protein 60   Chemotherapy Resistance   Mitochondrial Bioenergetics   Prostate Cancer Therapy  

Mitochondrial Unfolded Protein Response-Dependent β-Catenin Signaling Promotes Neuroendocrine Prostate Cancer Academic Background Prostate cancer is the second most commonly diagnosed cancer in American men, second only to skin cancer. Although current treatments, such as androgen deprivation therapy (ADT), can induce remission in prostate cancer, ...

Senescent Lung Fibroblasts in Idiopathic Pulmonary Fibrosis Facilitate Non-Small Cell Lung Cancer Progression by Secreting Exosomal MMP1

Medicine, Respiratory System, Oncology, Life Sciences, Cell Biology, Immunology,
Idiopathic Pulmonary Fibrosis   Non-Small Cell Lung Cancer   Exosomes   MMP1   PI3K-AKT-mTOR Pathway   Senescence-Associated Secretory Phenotype   Tumor Microenvironment  

Academic Background and Problem Statement Idiopathic Pulmonary Fibrosis (IPF) is a progressive interstitial lung disease associated with aging and is an independent risk factor for lung cancer. Epidemiological studies indicate that 3%-22% of IPF patients develop lung cancer during follow-up, with the cumulative incidence increasing over time, makin...

Lack of Dominant-Negative Activity for Tumor-Related ZNRF3 Missense Mutations at Endogenous Levels

Medicine, Gastroenterology, Oncology, Life Sciences, Cell Biology, Biochemistry,
ZNRF3   β-catenin signaling   missense mutations   tumor   Wnt signaling pathway  

Academic Background and Paper Introduction Background The Wnt/β-catenin signaling pathway is dysregulated in various cancers, particularly in colorectal and endometrial cancers. Abnormal activation of this pathway is often associated with mutations in tumor suppressor genes such as APC, AXIN1/2, and β-catenin itself. Additionally, RNF43 and ZNRF3, ...