Non-invasive MRI of blood-cerebrospinal fluid-barrier function in a mouse model of Alzheimer’s disease: a potential biomarker of early pathology

Medicine, Neurology, Medical Imaging,
Alzheimer’s disease   choroid plexus   blood-csf barrier   brain perfusion   arterial spin labelling MRI   3xTg mouse model  

Non-invasive MRI Study of Blood-Cerebrospinal Fluid Barrier Function in a Mouse Model of Alzheimer’s Disease Academic Background Alzheimer’s Disease (AD) is a common neurodegenerative disorder characterized by the accumulation of β-amyloid (Aβ) plaques and neurofibrillary tangles. Recent studies have increasingly shown that the Blood-Cerebrospinal ...

Phase-Contrast MRI Analysis of Cerebral Blood and CSF Flow Dynamic Interactions

Medicine, Neurology, Neurosurgery, Medical Imaging,
cerebral blood   CSF   volume change   intracranial   extracranial   flow dynamics   phase-contrast MRI  

Study on the Interaction Between Cerebral Blood Flow and Cerebrospinal Fluid Dynamics Measured at Intracranial and Extracranial Planes Background The interaction between cerebral blood flow (CBF) and cerebrospinal fluid (CSF) is a critical factor in maintaining intracranial pressure (ICP) stability. According to the Monro-Kellie doctrine, the intra...

Reduced Oxycodone Brain Delivery in Rats due to Lipopolysaccharide-Induced Inflammation: Microdialysis Insights into Brain Disposition and Sex-Specific Pharmacokinetics

Medicine, Anesthesiology, Pharmacy,
blood-brain barrier   oxycodone   microdialysis   sex-specific   lipopolysaccharides   inflammation   pharmacokinetics  

The Impact of Inflammation on Brain Delivery of Oxycodone Academic Background Oxycodone is a widely used opioid analgesic with a unique property of being actively transported from the blood to the brain across the blood-brain barrier (BBB). This process is believed to be associated with the proton-coupled organic cation (H+/OC) antiporter system. H...

The Influence of Glioblastoma Differentiation on Blood-Brain Barrier Permeability

Medicine, Neurology, Oncology,
Glioblastoma   Blood-Brain Barrier   Permeability   IL-6   STAT3   Tumor Differentiation   Drug Delivery  

The Impact of Glioblastoma Differentiation on Blood-Brain Barrier Permeability Background Introduction Glioblastoma Multiforme (GBM) is a highly aggressive brain tumor, and its treatment is extremely challenging due to its complex biological characteristics and the presence of the Blood-Brain Barrier (BBB). The BBB is a complex structure composed o...

Relaxation-Exchange Magnetic Resonance Imaging (REXI): A Non-Invasive Imaging Method for Evaluating Trans-Barrier Water Exchange in the Choroid Plexus

Medicine, Neurology, Medical Imaging, Life Sciences, Biophysics,
Magnetic Resonance Imaging   Choroid Plexus   Water Exchange   Non-Invasive   Cerebrospinal Fluid   Biomarker   Steady-State Water Efflux Rate  

Non-Invasive Imaging Technique for Evaluating Trans-Barrier Water Exchange in the Choroid Plexus Background Introduction The choroid plexus (CP) is a critical site for cerebrospinal fluid (CSF) production and an essential component of the blood-cerebrospinal fluid barrier (BCSFB). The CP regulates CSF secretion and absorption, maintaining brain hom...

Phosphorylation of BOK at Ser-8 Blocks Its Ability to Suppress IP3R-Mediated Calcium Mobilization

Medicine, Life Sciences, Cell Biology, Biochemistry,
BOK   phosphorylation   IP3R   calcium mobilization   endoplasmic reticulum   GPCR   calcium signaling  

The New Role of BOK Protein in Calcium Signaling Regulation Background Introduction BOK (Bcl-2-related ovarian killer) is a member of the Bcl-2 protein family and has long been thought to play a role in cell apoptosis. However, recent studies suggest that BOK may also have non-apoptotic functions, particularly in the regulation of calcium ion (Ca²⁺...