Long-term Outcome of the Milano-Hyperfractionated Accelerated Radiotherapy Strategy for High-Risk Medulloblastoma, Including the Impact of Molecular Subtype

Medicine, Neurology, Neurosurgery, Oncology,
high-risk medulloblastoma   hyperfractionated accelerated radiotherapy   molecular subtype   chemotherapy response   long-term survival  

Long-Term Outcomes of High-Risk Medulloblastoma Treatment Background Medulloblastoma is one of the most common malignant brain tumors in children. Despite advancements in treatment, the prognosis for high-risk medulloblastoma patients remains poor. High-risk medulloblastoma typically includes patients with metastatic disease, TP53 mutations, MYC/MY...

Molecular and Clinical Heterogeneity within MYC-Family Amplified Medulloblastoma is Associated with Survival Outcomes: A Multicenter Cohort Study

Medicine, Neurology, Neurosurgery, Oncology,
medulloblastoma   MYC amplification   clinical heterogeneity   molecular subgroups   survival outcomes   high-risk disease   treatment strategies  

Clinical and Biological Heterogeneity in MYC/MYCN-Amplified Medulloblastoma Academic Background Medulloblastoma (MB) is one of the most common malignant brain tumors in children. Despite recent advances in treatment, approximately 30% of patients still die from the disease, and survivors often face long-term treatment-related complications. Amplifi...

Distinct Relapse Patterns Across Molecular Ependymoma Types

Distinct Relapse Patterns Across Molecular Ependymoma Types

Medicine, Neurology, Neurosurgery, Oncology,
ependymoma   relapse patterns   molecular types   intracranial tumors   clinical research  

Study on Relapse Patterns of Intracranial Ependymoma Background Ependymoma (EPn) is a rare but highly heterogeneous central nervous system tumor, particularly common in children. Despite significant advances in the biology and molecular characteristics of ependymoma in recent years, its relapse patterns remain unclear. The timing and location of re...

Determining Risk Features for Medulloblastoma in the Molecular Era

Medicine, Pediatrics, Neurology, Oncology,
medulloblastoma   molecular classification   risk stratification   radiation therapy   methylation profiling   chemotherapy   survival rate  

Advances in Risk Stratification and Treatment Strategies for Medulloblastoma Background Medulloblastoma is a common malignant brain tumor in children, with significant differences in treatment and prognosis depending on its molecular subtypes. In recent years, advances in molecular biology have revealed that medulloblastoma can be further divided i...

Developmental Pluripotency-Associated 4 Increases Aggressiveness of Pituitary Neuroendocrine Tumors by Enhancing Cell Stemness

Medicine, Endocrinology, Oncology, Life Sciences, Cell Biology, Genetics,
pituitary neuroendocrine tumors   cell stemness   Wnt/β-catenin signaling   Dppa4 gene   tumor aggressiveness   epigenetics   stem cell regulation  

The Oncogenic Role of Dppa4 in Pituitary Neuroendocrine Tumors Academic Background Pituitary Neuroendocrine Tumors (PitNETs) are common intracranial tumors that often exhibit hormone-secreting functions and are a significant cause of hypogonadism and infertility in humans. Although most PitNETs can be controlled through surgery and medication, some...

PICK: Predict and Mask for Semi-Supervised Medical Image Segmentation

Information Science, Computer Science, Artificial Intelligence, Medicine, Medical Imaging,
semi-supervised learning   medical image segmentation   attentive region masking   reconstruction task   deep learning  

Report on the Paper “PICK: Predict and Mask for Semi-Supervised Medical Image Segmentation” Academic Background Accurate segmentation of medical images is crucial in clinical practice, as it provides vital insights into organ/tumor characteristics such as volume, location, and shape. Recent studies have highlighted the significant potential of data...