IL-22 Restores Gut Homeostasis and Alleviates Diet-Induced MASLD In recent years, the incidence of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) has significantly increased, closely related to the widespread consumption of high-energy diets rich in sugars and fats. MASLD is not only closely linked to metabolic diseases such as ob...

Novel Subpopulation of Adipose Tissue Macrophages IMAMs and Their Role in Obesity and Metabolic Disorders Background Obesity is an increasingly severe health issue worldwide, often accompanied by a state of chronic low-grade inflammation. This condition is driven by the infiltration and dysfunction of immune cells within adipose tissue and other me...

Comprehensive Clinical and Preclinical Studies Reveal the Therapeutic Potential of Ferroterminator1 (FOT1) for Metabolic-Associated Fatty Liver Disease (MAFLD) Background: Research Needs on MAFLD and Iron Overload Issues Metabolic-associated fatty liver disease (MAFLD), formerly known as non-alcoholic fatty liver disease (NAFLD), is a common chroni...

Integration of Electrophysiological and Genomic Analysis Reveals Tumor Cells Capable of Generating Action Potentials in Human Gliomas Background and Research Objectives Gliomas are the most common malignant tumors in the central nervous system, with approximately 20,000 new cases annually. These tumors include two subtypes: isocitrate dehydrogenase...

Cross-Organ Human Fibroblast Atlas Reveals Unique Roles of Different Myofibroblast Subtypes in Immune Regulation Research Background and Motivation Fibroblasts play critical roles in maintaining tissue homeostasis, inflammatory responses, fibrosis, and cancer progression. In recent years, the diversity of fibroblasts in the tumor microenvironment (...

Fibrotic Response Induced by Anti-CSF-1R Treatment Promotes Glioblastoma Recurrence Background Introduction Glioblastoma (GBM) is a highly aggressive and malignant primary tumor of the central nervous system. Although current standard treatments include surgical resection, Temozolomide chemotherapy, and fractionated radiotherapy, the median surviva...