Bidirectional Epigenetic Editing Reveals Hierarchies in Gene Regulation

Medicine, Life Sciences, Cell Biology, Immunology, Genetics, Biophysics,
Gene Regulation   Epigenetics   CRISPR Technology   Genetic Interactions   Transcription Factors  

Bidirectional Epigenetic Editing Reveals Hierarchies in Gene Regulation Background and Research Motivation In the human genome, the role of non-coding elements such as enhancers in gene regulation is widely recognized. However, current CRISPR interference methods still have some limitations in studying non-coding elements and genetic interactions. ...

Principled distillation of UK Biobank phenotype data reveals underlying structure in human variation

Medicine, Basic Medical Sciences, Life Sciences, Genetics,
UK Biobank   latent structure   human variation   health outcomes   genetic signal   data reduction   biological samples  

In this report, we present a detailed evaluation of a research paper published in the journal Nature Human Behaviour, titled “Principled Refinement of UK Biobank Phenotypic Data Reveals the Latent Structure of Human Variation.” The study, conducted by Caitlin E. Carey, Rebecca Shafee, Robbee Wedow, among others, was published online on XX XX, XXXX....

Multiplex Cerebrospinal Fluid Proteomics Identifies Biomarkers for Diagnosis and Prediction of Alzheimer's Disease

Medicine, Medical Laboratory Science, Neurology, Medical Imaging, Life Sciences, Cell Biology,
Alzheimer's Disease   Cerebrospinal Fluid   Proteomics   Biomarkers   Diagnosis   Prediction  

Cerebrospinal Fluid Proteomics Study for Diagnosis and Prediction of Alzheimer’s Disease Background and Research Objectives Alzheimer’s disease (AD) is a neurodegenerative disease that leads to memory loss and cognitive decline, and currently, there is no effective cure globally. Traditionally, the pathological features of AD include β-amyloid (Aβ)...

Gene × Environment Effects and Mediation Involving Adverse Childhood Events, Mood and Anxiety Disorders, and Substance Dependence

Medicine, Environmental and Public Health, Neurology,
adverse childhood events   mood disorders   anxiety disorders   substance dependence   gene-environment interaction   mediation   psychopathology  

Study on the Genetic and Environmental Effects of Adverse Childhood Events, Mood and Anxiety Disorders, and Substance Dependence I. Background and Significance Adverse childhood events (ACE) often have profound effects on an individual’s mental health and substance dependence. Previous studies have shown a close relationship between ACE and mood an...

Decision Uncertainty as a Context for Motor Memory

Medicine, Neurology, Sports Medicine, Life Sciences,
decision uncertainty   motor memory   perceptual decision-making   motor learning   contextual cues  

Decision Uncertainty as a Contextual Cue for Motor Memory Background In a penalty shootout during a soccer match, players may face two distinctly different decision-making scenarios. For example, a player may decisively kick the ball to the right corner after seeing the goalkeeper move to the other side, or he may kick the same way without being ce...

Mendelian Randomization Evidence for the Causal Effect of Mental Well-being on Healthy Aging

Medicine, Environmental and Public Health, Geriatrics, Humanities and Others,
Mental well-being   Healthy aging   Mendelian randomization   Causal effect   Genetic instruments  

Research Report: Causal Effects of Mental Well-being on Healthy Aging Research Background With the significant increase in average life expectancy, aging issues have become increasingly prominent. Challenges such as comorbidity, disability, and the overall social stability of healthcare services and finances have become more severe. Achieving healt...