Ventilation Practices in Acute Brain Injured Patients and Association with Outcomes: The Ventibrain Multicenter Observational Study

Academic Report on “Ventilation Practices in Acute Brain Injured Patients and Association with Outcomes: The Ventibrain Multicenter Observational Study” Academic Background Mechanical ventilation (MV) is a fundamental component of the intensive care unit (ICU) management of acute brain injury (ABI) patients. However, strong evidence on the best ven...

Discussing Expected Long-Term Quality of Life in the ICU: Effect on Experiences and Outcomes of Patients, Family, and Clinicians—A Randomized Clinical Trial

The Impact of Discussing Long-Term Quality of Life Predictions in the ICU on Patients, Families, and Healthcare Professionals Academic Background Patients discharged from the Intensive Care Unit (ICU) often face a range of physical, psychological, and cognitive issues, collectively referred to as Post-Intensive Care Syndrome (PICS). Despite improve...

Persistent Severe Acute Kidney Injury is a Major Modifiable Determinant of Outcome During Critical Illness

The Impact of Persistent Severe Acute Kidney Injury on Outcomes in Critically Ill Patients Background Introduction Acute Kidney Injury (AKI) is a common complication among hospitalized and critically ill patients, causing over 10 million deaths globally each year and serving as a significant risk factor for the progression of Chronic Kidney Disease...

ESICM Consensus-Based Recommendations for the Management of Very Old Patients in Intensive Care

ESICM Consensus: Management and Challenges of Very Old Patients in Critical Care Academic Background With the global aging population, the proportion of “very old patients” (aged 80 years and above) in intensive care units (ICUs) is rapidly increasing. This group is characterized by functional impairments and a high prevalence of complex multimorbi...

Are Contemporary Antifungal Doses Sufficient for Critically Ill Patients? Outcomes from an International, Multicenter Pharmacokinetics Study for Screening Antifungal Exposure in Intensive Care Units—The SAFE-ICU Study

International Multicenter Study Reveals Insufficient Antifungal Dosing in Critically Ill Patients Academic Background Invasive fungal infections are common and serious nosocomial infections, particularly among patients in the intensive care unit (ICU), where they are associated with high morbidity and mortality rates. Timely and appropriate antifun...

Impact of Rapid ICU-Based Syndromic PCR on Antibiotic Stewardship and Clinical Outcomes in Hospital-Acquired and Ventilator-Associated Pneumonia

INHALE WP3 Study - The Impact of Rapid PCR on ICU Antibiotic Stewardship and Clinical Outcomes Background Introduction Hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) are common infections in intensive care unit (ICU) patients, with an incidence rate between 5% to 40%, and are associated with high morbidity and increased...