PTDP-43 Levels Correlate with Cell Type–Specific Molecular Alterations in the Prefrontal Cortex of C9orf72 ALS/FTD Patients

Medicine, Neurology, Life Sciences, Cell Biology, Immunology, Genetics,
neurodegenerative disorders   PTDP-43   C9orf72   prefrontal cortex   single-nucleus multiome analysis  

Correlation between PTDP-43 Levels and Cell-Specific Molecular Alterations in the Prefrontal Cortex of C9orf72 ALS/FTD Patients Background Introduction Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are two types of progressive neurodegenerative diseases. Their common feature is the loss of specific neuronal populations in th...

Enhancing Passive Cavitation Imaging Using Pth Root Compression Delay, Sum, and Integrate Beamforming: In Vitro and In Vivo Studies

Engineering, Electrical Engineering, Information Science, Electronic Information, Medicine, Medical Imaging, Life Sciences, Bioengineering,
Passive Cavitation Imaging   Pth Root Compression   Beamforming   In Vitro Studies   In Vivo Studies   Ultrasound Therapy   Cavitation Monitoring  

Application of pth Root Compression Delay, Sum and Integrate Beamforming in Passive Cavitation Imaging Academic Background Passive Cavitation Imaging (PCI) is a technique used to monitor bubble activity during ultrasound therapy, widely applied in treatment scenarios such as drug delivery and tissue ablation (e.g., Histotripsy). However, existing P...

Modeling Tissue Electroporation: Effects of Electric Field Direction Change Between Pulses and Increased Conductivity in Post-IRE Regions

Engineering, Medicine, Oncology, Life Sciences, Bioengineering,
Irreversible Electroporation   Electric Field Direction Change   Post-IRE Regions   Conductivity   Numerical Model   Tumor Ablation   Treatment Planning  

Tissue Electroporation Modeling Research Background Introduction Electroporation is a phenomenon that occurs when cell membranes are exposed to short electrical pulses, increasing the permeability of the cell membrane to ions and macromolecules. Depending on the impact of electrical pulses on the cell membrane, electroporation can be classified as ...

Design, Fabrication and Test of a Lightweight 3.0 T Cryogen-Free MRI System

Engineering, Electrical Engineering, Medicine, Medical Imaging, Life Sciences, Bioengineering,
Cryogen-Free MRI System   Magnetic Field Stability   Small Animal Imaging   Material Analysis   Gradient Coil  

Design and Testing of a Lightweight 3.0 T Cryogen-Free MRI System Academic Background Magnetic Resonance Imaging (MRI), as a non-invasive, radiation-free imaging technology, has been widely used in medical diagnostics and scientific research. Especially in the fields of small animal studies and material analysis, high-field MRI systems can provide ...

Quantitative Ultrasonic Backscatter Evaluation of Elastic and Mechanical Properties in a Rabbit Tendinopathy Healing Model

Medicine, Orthopedics, Medical Imaging, Life Sciences, Bioengineering,
ultrasound backscatter   tendinopathy   elastic properties   mechanical properties   quantitative evaluation  

Application of Ultrasound Backscatter Technique in Quantitative Tendon Characterization Academic Background Tendinopathy is a common musculoskeletal disease characterized by alterations in the microstructure, composition, and cellular organization of tendons, leading to pain and decreased function. Tendinopathy is typically initiated by overuse and...

Analysis of Pelvis and Lower Limb Coordination in Stroke Patients Using Smartphone-Based Motion Capture

Information Science, Automation, Medicine, Neurology, Life Sciences, Bioengineering,
smartphone video   musculoskeletal multibody modelling   intersegment coordination   hemiplegic gait  

Analysis of Pelvis and Lower Limb Coordination in Stroke Patients Using Smartphone-Based Motion Capture Technology Academic Background Stroke is one of the diseases with the highest incidence, disability, and mortality rates worldwide, with up to 15 million new cases each year. Among them, 20%-30% of stroke patients develop hemiplegic gait, which i...