Evaluating Generalizability of Oncology Trial Results to Real-World Patients Using Machine Learning-Based Trial Emulations

Information Science, Artificial Intelligence, Medicine, Oncology,
oncology   randomized controlled trials   machine learning   generalizability   real-world data   prognostic models   survival analysis  

Evaluation of the Generalizability of Oncology Trial Results Using Machine Learning-Based Trial Emulations Academic Background Randomized Controlled Trials (RCTs) are the gold standard for evaluating the efficacy of anti-cancer drugs, but their results often cannot be directly generalized to real-world oncology patients. RCTs typically employ stric...

Clinicogenomic Landscape of Pancreatic Adenocarcinoma Identifies KRAS Mutant Dosage as Prognostic of Overall Survival

Medicine, Hepatobiliary System, Gastroenterology, Oncology,
pancreatic cancer   KRAS mutation   genomic landscape   prognostic marker   clinical study  

Clinicogenomic Landscape of Pancreatic Ductal Adenocarcinoma: The Prognostic Role of KRAS Mutation Dosage Academic Background Pancreatic ductal adenocarcinoma (PDAC), the most common histological type of pancreatic cancer, is the third leading cause of cancer-related mortality and has the lowest five-year survival rate among all cancer types. Over ...

High-Efficiency Base Editing in the Retina of Primates and Human Tissues

Medicine, Ophthalmology, Life Sciences, Biochemistry, Bioengineering, Genetics,
base editing   retina   gene therapy   primates   Stargardt disease  

High-precision Base Editing Technology in Primates and Human Retina Research Background Stargardt disease is a currently untreatable, inherited neurodegenerative disease that leads to macular degeneration and blindness due to loss-of-function mutations in the ABCA4 gene. The protein encoded by the ABCA4 gene is a membrane lipid flippase localized i...

Reduced-Energy Diet in Women with Gestational Diabetes: The Dietary Intervention in Gestational Diabetes DIGEST Randomized Clinical Trial

Medicine, Obstetrics and Gynecology, Endocrinology,
Gestational Diabetes   Reduced-Energy Diet   Randomized Clinical Trial   Weight Management   Perinatal Outcomes  

Research Report on Low-Energy Diet Intervention in Gestational Diabetes Academic Background Gestational Diabetes Mellitus (GDM) is a form of diabetes diagnosed for the first time during pregnancy, with a global incidence rate of approximately 6-15%. GDM not only increases the risk of short-term complications for both mothers and fetuses, such as la...

Management of High-Risk Acute Pulmonary Embolism: An Emulated Target Trial Analysis

Medicine, Respiratory System, Emergency Medicine, Cardiovascular System,
High-risk pulmonary embolism   Systemic thrombolysis   Surgical thrombectomy   Percutaneous catheter-directed treatment   Mechanical circulatory support  

Target Trial Emulation Analysis for the Management of High-Risk Acute Pulmonary Embolism Background Introduction Acute pulmonary embolism (PE) is a life-threatening cardiovascular disease affecting more than 35 people per 100,000 annually. Approximately 5% of PE patients present with persistent hypotension, cardiogenic shock, or cardiac arrest, oft...

Ventilation Practices in Acute Brain Injured Patients and Association with Outcomes: The Ventibrain Multicenter Observational Study

Medicine, Neurology,
mechanical ventilation   acute brain injury   traumatic brain injury   cerebrovascular disease   outcome  

Academic Report on “Ventilation Practices in Acute Brain Injured Patients and Association with Outcomes: The Ventibrain Multicenter Observational Study” Academic Background Mechanical ventilation (MV) is a fundamental component of the intensive care unit (ICU) management of acute brain injury (ABI) patients. However, strong evidence on the best ven...