Inhibiting Cell Inspection Points Intervention via Injectable Short Fibers for Reversing Neural Cell Senescence

Medicine, Neurology, Neurosurgery, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
neural cell senescence   inspection point   short fibers   spinal cord   genome homeostasis  

Background Introduction Spinal Cord Injury (SCI) is a significant challenge in the medical field, particularly in terms of neural function recovery. Research indicates that neurons play a crucial role in spinal cord regeneration, but in complex pathological environments, neurons are influenced by various factors, leading to rapid senescence. Senesc...

A Time-Scheduled Oxygen Modulation System Facilitates Bone Regeneration by Powering Periosteal Stem Cells

Medicine, Orthopedics, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
bone regeneration   periosteal stem cells   remote control   oxygen delivery   rapid neovascularization  

Academic Background During tissue repair, chronic hypoxia negatively impacts the functionality of stem cells. Periosteal Stem Cells (PSCs), as the primary contributors to bone repair, exhibit unclear behavior under hypoxic conditions. While hypoxia may be beneficial for certain stem cells in the early stages of tissue repair, prolonged hypoxia can ...

A Portable, Sprayable, Highly Malleable, Elastic, and Hydrophobic Antibacterial Fibrous Wound Dressing for Infected Wound Healing

Chemistry, Nanoscience, Polymer Chemistry, Materials Science, Organic Polymeric Materials, Medicine, Infectious Diseases, Life Sciences, Bioengineering,
wound dressing   antibacterial   hydrophobic   malleability   solution blow spinning   infected wound   wound healing  

Academic Background Wound infection is a significant concern for patients and healthcare professionals worldwide, particularly in the management of severe wounds. Inappropriate dressings can increase the risk of infection, prolong healing time, and even lead to higher mortality rates and economic burdens. Traditional wound dressings, such as gauze ...

Bioactive MgO/MgCO3/Polycaprolactone Multi-Gradient Fibers Facilitate Peripheral Nerve Regeneration by Regulating Schwann Cell Function and Activating Wingless/Integrase-1 Signaling

Chemistry, Polymer Chemistry, Materials Chemistry, Materials Science, Metallic Materials, Medicine, Neurology,
magnesium   multi-gradient fibers   Schwann cells   Wnt signaling pathway   peripheral nerve regeneration  

Study on Peripheral Nerve Regeneration Based on Multi-Gradient MgO/MgCO₃/PCL Nanofiber Membranes Academic Background Peripheral nerve defects are a common and complex orthopedic issue in clinical practice, with limited efficacy of current treatments. The insufficient proliferation and dysfunction of Schwann cells within nerve scaffolds are key fact...

Super-Elastic Phenylalanine Dipeptide Crystal Fibers Enable Monolithic Stretchable Piezoelectrics for Wearable and Implantable Bioelectronics

Chemistry, Nanoscience, Polymer Chemistry, Materials Chemistry, Materials Science, Medicine, Life Sciences, Bioengineering,
piezoelectric materials   nanoconfinement self-assembly   phenylalanine dipeptide   stretchable sensor   wireless motion monitor  

Super-Elastic Phenylalanine Dipeptide Crystal Fibers in Wearable and Implantable Bioelectronics Background With the rapid development of flexible bioelectronics, the development of piezoelectric materials and devices with high elasticity, breathability, and the ability to achieve conformal deformation with the human body has become an important res...

A Polyphenol–Metal Network of Propyl Gallate Gallium/Hafnium Oxide on Polyimide Fibers for Facilitating Ligament–Bone Healing

Chemistry, Polymer Chemistry, Materials Science, Organic Polymeric Materials, Medicine, Orthopedics, Sports Medicine, Life Sciences, Bioengineering,
polyimide fiber   artificial ligament   osteogenesis   anti-bacteria   anti-inflammation   ligament–bone healing  

Study on Surface Modification of Polyimide Fibers to Promote Ligament-Bone Healing Academic Background Anterior Cruciate Ligament (ACL) injury is one of the most common sports injuries worldwide, with approximately 1 in 1,250 people requiring ACL reconstruction surgery each year. Currently, the main methods for ACL reconstruction include autografts...