A Polyphenol–Metal Network of Propyl Gallate Gallium/Hafnium Oxide on Polyimide Fibers for Facilitating Ligament–Bone Healing

Chemistry, Polymer Chemistry, Materials Science, Organic Polymeric Materials, Medicine, Orthopedics, Sports Medicine, Life Sciences, Bioengineering,
polyimide fiber   artificial ligament   osteogenesis   anti-bacteria   anti-inflammation   ligament–bone healing  

Study on Surface Modification of Polyimide Fibers to Promote Ligament-Bone Healing Academic Background Anterior Cruciate Ligament (ACL) injury is one of the most common sports injuries worldwide, with approximately 1 in 1,250 people requiring ACL reconstruction surgery each year. Currently, the main methods for ACL reconstruction include autografts...

Neoadjuvant Nivolumab and Chemotherapy in Early Estrogen Receptor-Positive Breast Cancer: A Randomized Phase 3 Trial

Medicine, Oncology,
breast cancer   neoadjuvant chemotherapy   nivolumab   estrogen receptor-positive   randomized trial  

Neoadjuvant Nivolumab and Chemotherapy in Early Estrogen Receptor-Positive Breast Cancer Academic Background Breast cancer is one of the most common cancers among women worldwide, with estrogen receptor-positive (ER+) and human epidermal growth factor receptor 2-negative (HER2−) breast cancer accounting for the majority of cases. Although ER+/HER2−...

Multi-omics-based Mapping of Decidualization Resistance in Patients with a History of Severe Preeclampsia

Medicine, Obstetrics and Gynecology, Life Sciences,
Decidualization resistance   Severe preeclampsia   Multi-omics analysis   Endometrium   Cell-cell communication  

Multi-omics technology reveals the mechanism of endometrial decidualization resistance in patients with severe preeclampsia Academic background Preeclampsia (PE) is a common and serious complication during pregnancy, primarily characterized by hypertension, proteinuria, and dysfunction of other organs, posing a significant threat to maternal and fe...

Pembrolizumab and Chemotherapy in High-Risk, Early-Stage, ER+/HER2− Breast Cancer: A Randomized Phase 3 Trial

Medicine, Oncology,
breast cancer   pembrolizumab   chemotherapy   randomized trial   pathological complete response  

Pembrolizumab Combined with Chemotherapy in High-Risk, Early-Stage ER+/HER2− Breast Cancer: A Randomized Phase 3 Trial Academic Background Breast cancer is one of the most common cancers among women worldwide, with estrogen receptor-positive/human epidermal growth factor receptor 2-negative (ER+/HER2−) breast cancer accounting for a significant pro...

Genomic Reanalysis of a Pan-European Rare-Disease Resource Yields New Diagnoses

Medicine, Life Sciences, Genetics,
rare diseases   genomic reanalysis   European collaboration   diagnostic yield   genetic variants  

European Genomic Reanalysis of Rare Diseases: New Diagnoses and Future Blueprint Academic Background Rare diseases are defined as conditions affecting a very small proportion of the population, with the European Union setting the threshold at fewer than 50 individuals per 100,000. Despite the vast diversity of rare diseases (over 6,000 types), more...

Evaluating Generalizability of Oncology Trial Results to Real-World Patients Using Machine Learning-Based Trial Emulations

Information Science, Artificial Intelligence, Medicine, Oncology,
oncology   randomized controlled trials   machine learning   generalizability   real-world data   prognostic models   survival analysis  

Evaluation of the Generalizability of Oncology Trial Results Using Machine Learning-Based Trial Emulations Academic Background Randomized Controlled Trials (RCTs) are the gold standard for evaluating the efficacy of anti-cancer drugs, but their results often cannot be directly generalized to real-world oncology patients. RCTs typically employ stric...