Inflammatory Proteins and Hidradenitis Suppurativa: Insights from Genetic Correlation and Mendelian Randomization

Medicine, Life Sciences, Immunology, Genetics, Microbiology,
Hidradenitis Suppurativa   Inflammatory Proteins   Genetic Correlation   Mendelian Randomization   Causal Relationship  

Inflammatory Proteins and Hidradenitis Suppurativa: Insights from Genetic Correlation and Mendelian Randomization Studies Research Background Hidradenitis Suppurativa (HS) is a chronic inflammatory skin disease characterized by recurrent nodules, abscesses, and sinus tracts, commonly found in areas of skin friction such as the armpits, groin, peria...

Traumatic Experiences, Dissociative Symptoms, and Alexithymia in Patients with Alopecia Areata

Medicine, Environmental and Public Health, Psychiatry,
alopecia areata   childhood trauma   dissociative disorder   posttraumatic stress disorder   alexithymia   mental health   dermatology  

Traumatic Experiences, Dissociative Symptoms, and Alexithymia in Patients with Alopecia Areata Academic Background Alopecia Areata (AA) is an inflammatory autoimmune disease targeting hair follicles, with its exact etiology remaining unclear. Studies suggest that genetic, environmental, autoimmune, and psychological factors may play significant rol...

Prognostic Value of the CONUT Score with Immune Checkpoint Inhibitors as First-Line Therapy for Metastatic Malignant Melanoma

Medicine, Oncology, Life Sciences, Immunology,
Immune checkpoint inhibitors   Nutritional status   Melanoma   Prognostic marker   Inflammation  

Prognostic Value of the CONUT Score in Immune Checkpoint Inhibitor Therapy for Metastatic Malignant Melanoma Academic Background The incidence of malignant melanoma (MM) is increasing annually, with approximately 20% of patients progressing to advanced or metastatic melanoma. Immune checkpoint inhibitors (ICIs) have significantly transformed the tr...

Prevalence and Incidence of Comorbidities in Patients with Atopic Dermatitis, Psoriasis, Alopecia Areata, and Vitiligo Using a Japanese Claims Database

Medicine, Infectious Diseases, Rheumatology and Immunology, Oncology, Cardiovascular System, Life Sciences, Immunology,
comorbidities   atopic dermatitis   psoriasis   alopecia areata   vitiligo   Japan   health claims database  

Prevalence and Incidence of Comorbidities in Japanese Patients with Dermatologic Diseases Academic Background Dermatologic diseases such as atopic dermatitis (AD), psoriasis, alopecia areata (AA), and vitiligo are common chronic inflammatory or autoimmune skin disorders. These conditions not only significantly impact patients’ quality of life but a...

Infiltration of M2a Macrophages is Predominant in Genital Verruciform Xanthoma

Medicine, Life Sciences, Immunology,
M2a macrophages   verruciform xanthoma   genital   immunohistochemistry   pathology  

Predominant Infiltration of M2a Macrophages in Genital Verruciform Xanthoma Academic Background Verruciform xanthoma (VX) is a rare benign verrucous tumor first reported by Sachs in 1903 and formally named by Shafer in 1971. This lesion primarily occurs in the genital area and oral mucosa of elderly individuals. Histopathologically, it is character...

Validation of Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) Score and Establishment of Novel Score in Japanese Patients with Necrotizing Fasciitis (J-LRINEC Score)

Medicine, Infectious Diseases,
necrotizing fasciitis   LRINEC score   Japanese patients   sensitivity   specificity   skin infection   J-LRINEC  

A Report on the Validation of the Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) Score and the Establishment of a Novel Score (J-LRINEC) in Japanese Patients Academic Background Necrotizing fasciitis (NF) and cellulitis are two common skin infectious diseases. Although they share some similarities in clinical manifestations, their sev...