Characteristics of Suitable Cases for Treatment with Nemolizumab Based on Clinical Findings and Cutaneous Adverse Events

Medicine,
nemolizumab   atopic dermatitis   cutaneous adverse events   treatment optimization   inflammatory response   patient management   treatment continuation  

Characteristics of Suitable Cases for Nemolizumab Treatment Based on Clinical Findings and Cutaneous Adverse Events Academic Background Atopic Dermatitis (AD) is a common chronic inflammatory skin disease, characterized by intense itching that significantly impacts patients’ quality of life. In recent years, treatment methods for AD have advanced, ...

Stochastic Modeling of Single-Cell Gene Expression Adaptation Reveals Non-Genomic Contribution to Evolution of Tumor Subclones

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
stochastic modeling   gene expression adaptation   tumor subclones   Wnt signaling   immunotherapy   non-genomic contribution   cellular evolution  

Stochastic Modeling of Single-Cell Gene Expression Adaptation Reveals Non-Genomic Contribution to Tumor Subclone Evolution Academic Background Cancer is a complex disease whose progression is driven by the evolution of cells that are selected through adaptive advantages for growth. Traditionally, cancer evolution research has focused primarily on g...

Contrastive Learning of T Cell Receptor Representations

Medicine, Life Sciences, Cell Biology, Biochemistry, Immunology,
T cell receptor   contrastive learning   sequence alignment   specificity prediction   language model  

New Breakthrough in T Cell Receptor (TCR) Specificity Prediction: The Introduction of the SCEPTR Model Academic Background T cell receptors (TCRs) play a crucial role in the immune system by determining the specificity of immune responses through their binding to peptide-MHC complexes (pMHCs). Understanding the interaction between TCRs and specific...

Study Reveals CDK2 Activity Crosstalk in ERK Kinase Translocation Reporter

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry,
ERK kinase   CDK2 activity   single-cell imaging   signaling pathway   computational methods  

CDK2 Activity Interference on ERK and p38 KTR Signals and Computational Correction Methods Recently, a paper published in Cell Systems by authors Timothy E. Hoffman, Chengzhe Tian, Varuna Nangia, and others revealed the interference of cyclin-dependent kinase 2 (CDK2) on the kinase translocation reporter (KTR) signals in the extracellular signal-re...

Modular Brain-Machine Interface for Neurorecording, Neurostimulation, and Drug Delivery

Modular Brain-Machine Interface for Neurorecording, Neurostimulation, and Drug Delivery

Engineering, Electrical Engineering, Medicine, Neurology, Life Sciences, Bioengineering,
Brain-Machine Interface   Modular Design   Neurorecording   Neurostimulation   Drug Delivery   Multimodal   Wireless Technology  

Modular Brain-Machine Interface: Innovative Breakthrough in Neurorecording, Neurostimulation, and Drug Delivery Academic Background Brain-Machine Interfaces (BMIs) are crucial tools in neuroscience and clinical medicine, enabling interactions between the brain and the external world through charge, matter, and information exchange. They are widely ...

Improving Glioblastoma Treatment with Imaging, Radiotherapy, Drug Delivery, and Therapeutic Systems

Medicine, Neurology, Neurosurgery, Medical Imaging, Oncology,
glioblastoma   imaging techniques   radiotherapy   drug delivery systems   therapeutic devices  

Improving Glioblastoma Treatment with Imaging, Radiotherapy, Drug Delivery, and Therapeutic Systems Academic Background Glioblastoma (GBM) is the most common and aggressive type of brain cancer, with an extremely poor prognosis and a five-year survival rate of less than 10%. Despite decades of extensive research in drug therapy, radiation therapy, ...