Melatonin Alleviates High Temperature Exposure Induced Fetal Growth Restriction via the Gut-Placenta-Fetus Axis in Pregnant Mice

Melatonin Alleviates High Temperature Exposure-Induced Fetal Growth Restriction via the Gut-Placenta-Fetus Axis Research Background Global climate warming has become a significant threat to human health, particularly affecting pregnant women and fetuses. Studies have shown that high-temperature exposure increases the risk of adverse pregnancy outco...

Achieving Healthy Aging Through Gut Microbiota-Directed Dietary Intervention: Focusing on Microbial Biomarkers and Host Mechanisms

Achieving Healthy Aging through Gut Microbiota-Directed Dietary Intervention: Focusing on Microbial Biomarkers and Host Mechanisms Academic Background With the intensification of global population aging, preventing age-related diseases and extending healthy life expectancy have become critical issues in global public health. Gut microbiota has been...

Identification of a Transcription Factor Aomsn2 of the HOG1 Signaling Pathway Contributes to Fungal Growth, Development and Pathogenicity in Arthrobotrys oligospora

The Role of Transcription Factor AoMsn2 in the Hog1 Signaling Pathway in Fungal Growth, Development, and Pathogenicity Background Plant-parasitic nematodes cause significant annual losses to agriculture, while nematode-trapping fungi (NT fungi), due to their ability to capture nematodes by forming specialized trapping structures, have gradually bec...

Exploring the Impacts of Senescence on Implantation and Early Embryonic Development

Exploring the Impacts of Senescence on Implantation and Early Embryonic Development Using Totipotent Cell-Derived Blastoids Academic Background With the increasing trend of delayed childbearing in modern society, reproductive issues among women of advanced maternal age (AMA) have become increasingly prominent. Studies have shown that the implantati...

Unlocking Melanoma Suppression: Insights from Plasma-Induced Potent miRNAs through PI3K-AKT-ZEB1 Axis

Study on Melanoma Suppression by Non-Thermal Atmospheric Pressure Plasma via the PI3K-AKT-ZEB1 Axis Academic Background Melanoma is the most aggressive and deadly form of skin cancer, particularly in its advanced stages, making treatment extremely challenging. Although recent advancements in targeted therapy and immunotherapy have improved patient ...

Inflammatory Proteins and Hidradenitis Suppurativa: Insights from Genetic Correlation and Mendelian Randomization

Inflammatory Proteins and Hidradenitis Suppurativa: Insights from Genetic Correlation and Mendelian Randomization Studies Research Background Hidradenitis Suppurativa (HS) is a chronic inflammatory skin disease characterized by recurrent nodules, abscesses, and sinus tracts, commonly found in areas of skin friction such as the armpits, groin, peria...