Genomic Surveillance of Multidrug-Resistant Organisms Based on Long-Read Sequencing

Medicine, Infectious Diseases, Environmental and Public Health, Life Sciences, Genetics, Microbiology,
genomic surveillance   multidrug-resistant organisms   long-read sequencing   nanopore sequencing   MLST   WGMLST   WGS  

Genomic Surveillance of Multidrug-Resistant Organisms Based on Long-Read Sequencing Research Background Multidrug-resistant organisms (MDROs) are a significant global public health threat. These organisms exhibit resistance to multiple antibiotics, making infections challenging to treat and increasing healthcare costs. To effectively monitor and co...

Kynurenine-AHR Reduces T-Cell Infiltration and Induces a Delayed T-Cell Immune Response by Suppressing the STAT1-CXCL9/CXCL10 Axis in Tuberculosis

Medicine, Infectious Diseases, Life Sciences, Immunology,
tuberculosis   tryptophan metabolism   IDO1   immunosuppression   chemokines   T-cell infiltration   STAT1 signaling pathway  

Research Background and Motivation Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a global health issue infecting and killing millions annually. Despite advances in TB diagnosis and treatment, the immune evasion strategies employed by Mtb remain a critical reason for its prolonged survival in the host, leading to chronic infectio...

Century-Old Herbarium Specimen Provides Insights into Pierce’s Disease of Grapevines Emergence in the Americas

Medicine, Infectious Diseases, Life Sciences, Botany, Microbiology,
Pierce's disease   herbarium specimen   genome sequencing   pathogen introduction   historical genomics  

Summary of the Academic Paper Report on “Century-Old Herbarium Specimen Provides Insights Into Pierce’s Disease of Grapevines Emergence in the Americas” Introduction Pierce’s Disease (PD) of grapevines, caused by the bacterial subspecies Xylella fastidiosa subsp. fastidiosa (Xff), poses a severe threat to the viticulture industry. However, its geog...

Recombinant vs Egg-Based Quadrivalent Influenza Vaccination for Nursing Home Residents: A Cluster Randomized Trial

Medicine, Infectious Diseases, Geriatrics,
influenza vaccine   nursing home   randomized trial   recombinant vaccine   egg-based vaccine   hospitalization rates   COVID-19  

Comparative Analysis of Recombinant Quadrivalent Influenza Vaccine and Standard Egg-Based Quadrivalent Influenza Vaccine in Nursing Home Residents: A Cluster Randomized Trial Academic Background Influenza is among the primary respiratory pathogens causing morbidity and mortality among the elderly worldwide, particularly in nursing home residents wh...

Validation of the Online Collaborative Ocular Tuberculosis Study Calculator for Tubercular Uveitis

Medicine, Infectious Diseases, Ophthalmology, Life Sciences, Immunology,
Tubercular Uveitis   Antitubercular Therapy   Diagnostic Accuracy   Clinical Decision-Making   International Cohort   Ocular Tuberculosis   COTS Calculator  

Academic Background Tubercular Uveitis (TBU) is an ocular condition caused by Mycobacterium tuberculosis infection or immune-mediated inflammation. While tuberculosis (TB) remains a major global public health issue, the diagnosis and treatment of TBU continue to pose significant challenges. TBU presents a wide range of clinical manifestations, with...

Impact of an Epstein-Barr Virus Serology-Based Screening Program on Nasopharyngeal Carcinoma Mortality: A Cluster-Randomized Controlled Trial

Medicine, Infectious Diseases, Oncology,
Nasopharyngeal carcinoma   Epstein-Barr virus   Screening   Mortality   Cluster-randomized controlled trial  

Impact of an Epstein-Barr Virus Serology-Based Screening Program on Nasopharyngeal Carcinoma Mortality: A Cluster-Randomized Controlled Trial Academic Background Nasopharyngeal carcinoma (NPC) is a malignant tumor that is highly prevalent in Asia, particularly in southern China. Approximately 85% of NPC cases occur in Asia, with the incidence being...