Targeted Nuclear Degranulation of Neutrophils Promotes the Progression of Pneumonia in Ulcerative Colitis

Medicine, Infectious Diseases, Rheumatology and Immunology, Gastroenterology, Life Sciences, Immunology,
neutrophils   targeted nuclear degranulation   ulcerative colitis   pneumonia   immune cell migration  

Academic Background Ulcerative Colitis (UC) is a chronic inflammatory bowel disease often accompanied by various extraintestinal complications, among which pulmonary infections are particularly severe. Although previous studies have indicated interactions between the intestinal and pulmonary immune systems, the specific mechanisms involving neutrop...

Interleukin-12p40 Deficiency Attenuates Myocardial Ferroptosis in Doxorubicin-Induced Chronic Cardiomyopathy by Inhibiting Th17 Differentiation and Interleukin-17A Production

Medicine, Rheumatology and Immunology, Cardiovascular System, Life Sciences, Cell Biology, Immunology,
Interleukin-12p40   Doxorubicin-induced cardiotoxicity   Ferroptosis   Inflammation   Adaptive immunity   T lymphocyte differentiation  

Academic Background Doxorubicin (Dox) is an anthracycline drug widely used in the treatment of tumors, but it exhibits dose-dependent cardiotoxicity, potentially leading to cardiomyopathy and heart failure. Despite its significant anticancer effects, the cardiotoxicity of Dox limits its clinical application. Currently, Dexrazoxane is the only FDA-a...

Translocating Gut Pathobiont Enterococcus Gallinarum Induces Th17 and IgG3 Anti-RNA Directed Autoimmunity in Mouse and Human

Medicine, Rheumatology and Immunology, Nephrology, Life Sciences, Immunology,
autoimmunity   gut microbiota   Th17 cells   IgG3 antibodies   systemic lupus erythematosus  

Academic Background Chronic autoimmune diseases are typically triggered by a combination of genetic predisposition and environmental factors, with complex and incompletely understood mechanisms. In many cases, these diseases require lifelong immunosuppressive treatments, imposing a heavy burden on patients. Recent research has found that gut microb...

Intestinal Epithelium–Derived IL-34 Reprograms Macrophages to Mitigate Gastrointestinal Tract Graft-Versus-Host Disease

Medicine, Rheumatology and Immunology, Basic Medical Sciences, Gastroenterology, Hematology, Life Sciences, Cell Biology, Immunology,
Graft-versus-host disease   Macrophages   IL-34   Intestinal epithelium   Immunomodulation  

Academic Report on the Role of Intestinal Epithelium-Derived IL-34 in Alleviating Graft-versus-Host Disease 1. Academic Background Graft-versus-Host Disease (GVHD) is a severe complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT), and gastrointestinal (GI) GVHD is the primary determinant of morbidity and mortality du...

Organ-Specific Microenvironments Drive Divergent T Cell Evolution in Acute Graft-Versus-Host Disease

Medicine, Rheumatology and Immunology, Hepatobiliary System, Respiratory System, Gastroenterology, Hematology, Life Sciences, Immunology,
Graft-versus-host disease   T cell evolution   Organ microenvironment   Immunopathology   Single-cell RNA sequencing  

Study on Organ-Specific T Cell Differentiation in Acute Graft-Versus-Host Disease (AGVHD) Academic Background Acute Graft-Versus-Host Disease (AGVHD) is a common and severe complication following Allogeneic Hematopoietic Stem Cell Transplantation (HCT), caused by the immune attack of donor T cells on host tissues. Although the pathological mechanis...

Perinatal Dysfunction of Innate Immunity in Cystic Fibrosis

Medicine, Infectious Diseases, Pediatrics, Rheumatology and Immunology, Respiratory System, Life Sciences, Immunology,
Cystic Fibrosis   Innate Immunity   Perinatal   Lung Damage   Inflammation   Monocytes   Transcriptomic Profiling  

Study on Congenital Immune Dysfunction in Cystic Fibrosis Research Background Cystic Fibrosis (CF) is a genetic disease caused by mutations in the CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) gene, primarily affecting the lungs and digestive system. One of the major problems faced by CF patients is recurrent infections and inflammatio...