A Hierarchy of Intestinal Antigens Instructs the CD4+ T Cell Receptor Repertoire

Medicine, Infectious Diseases, Rheumatology and Immunology, Gastroenterology, Life Sciences, Immunology,
intestinal immunity   T cell receptor   microbiota   dietary antigens   inflammatory bowel disease  

I. Research Background The intestinal immune system must balance tolerance and defense against dietary antigens, microbiota-derived antigens, and self-antigens. Although CD4+ T cells are known to play a central role in gut immunity, how different antigen sources shape the composition of the T cell receptor (TCR) repertoire remains unclear. The trad...

NF-κB-Mediated Developmental Delay Extends Lifespan in Drosophila

Medicine, Rheumatology and Immunology, Endocrinology, Life Sciences, Cell Biology, Immunology, Genetics,
developmental delay   lifespan extension   NF-κB signaling   innate immunity   Drosophila  

1. Research Background Aging has long been viewed as a gradual decline in physiological function with age. However, mounting evidence indicates that developmental programs profoundly influence aging outcomes. For instance, developmental time (the time required for an organism to reach maturity) shows a significant positive correlation with adult li...

Development and Characterization of Baricitinib Nanoemulgel with Antiarthritic Effect in Rats

Chemistry, Nanoscience, Medicinal Chemistry, Medicine, Rheumatology and Immunology, Pharmacy, Life Sciences, Bioengineering,
Baricitinib   Transdermal delivery   Nanoemulgel   Skin permeation   Antiarthritis activity  

Academic Background Rheumatoid Arthritis (RA) is a chronic autoimmune disease that primarily affects the synovial membrane of joints, leading to inflammation and erosive lesions. Approximately 0.5% to 1% of the global population is affected by this disease, particularly among the elderly, who often experience dysphagia, which limits the compliance ...

CRISPR-dCas9 Activation of TSG-6 in MSCs Modulates the Cargo of MSC-Derived Extracellular Vesicles and Attenuates Inflammatory Responses in Human Intervertebral Disc Cells In Vitro

Medicine, Rheumatology and Immunology, Orthopedics, Life Sciences, Cell Biology, Immunology,
CRISPR-dCas9   TSG-6   Mesenchymal Stem Cells   Extracellular Vesicles   Intervertebral Disc Cells   Inflammatory Responses   Genomic Engineering  

Intervertebral Disc Degeneration (IVDD) is one of the leading causes of low back pain worldwide, significantly impacting patients’ quality of life. IVDD is often accompanied by inflammatory responses, leading to the degradation of the extracellular matrix (ECM) and structural damage. Although cell therapies, such as mesenchymal stem cells (MSCs), h...

Fourth-Generation Chimeric Antigen Receptor T-Cell Therapy is Tolerable and Efficacious in Treatment-Resistant Rheumatoid Arthritis

Medicine, Rheumatology and Immunology, Life Sciences, Immunology,
Chimeric Antigen Receptor T-Cell   Rheumatoid Arthritis   Treatment-Resistant   Autoimmune Disease   Cell Therapy  

Rheumatoid Arthritis (RA) is an autoimmune inflammatory disease characterized by symmetric synovitis, leading to progressive functional disability in patients. Although monoclonal antibody therapies targeting cytokines (e.g., tumor necrosis factor-α, TNFα) and B cells (e.g., CD20-targeted antibody rituximab) have significantly improved RA treatment...

Targeted Nuclear Degranulation of Neutrophils Promotes the Progression of Pneumonia in Ulcerative Colitis

Medicine, Infectious Diseases, Rheumatology and Immunology, Gastroenterology, Life Sciences, Immunology,
neutrophils   targeted nuclear degranulation   ulcerative colitis   pneumonia   immune cell migration  

Academic Background Ulcerative Colitis (UC) is a chronic inflammatory bowel disease often accompanied by various extraintestinal complications, among which pulmonary infections are particularly severe. Although previous studies have indicated interactions between the intestinal and pulmonary immune systems, the specific mechanisms involving neutrop...