Skin-Permeable Gold Nanoparticles with Azelamide Monoethanolamine Modifications Ameliorate Inflammatory Skin Diseases

Chemistry, Nanoscience, Medicinal Chemistry, Materials Science, Medicine, Rheumatology and Immunology, Life Sciences, Immunology,
gold nanoparticles   azelamide monoethanolamine   skin inflammation   topical therapeutics   oxidative stress   matrix metalloproteinase   superoxide dismutase  

Report on the Academic Paper Inflammatory skin diseases, such as psoriasis and rosacea, are common chronic skin conditions worldwide, significantly impacting patients’ quality of life. Traditional topical drug delivery methods, while simple and non-invasive, suffer from poor skin penetration and long-term side effects. Therefore, developing an effe...

Osteochondral Abnormalities on Three-Dimensional Ultrashort Echo Time MRI Scans Are Associated with Knee Cartilage Degradation

Medicine, Rheumatology and Immunology, Orthopedics, Medical Imaging,
osteochondral abnormalities   knee cartilage degradation   three-dimensional ultrashort echo time MRI   osteochondral junction abnormalities   cartilage degradation grade  

Osteochondral Abnormalities on Three-Dimensional Ultrashort Echo Time MRI Scans Are Associated with Knee Cartilage Degradation Academic Background Osteoarthritis (OA) is the most prevalent musculoskeletal disease, characterized by pain and disability. A hallmark of OA is the progressive loss of articular hyaline cartilage, which connects to the sub...

Chemical Activation of Mitochondrial CLPP to Modulate Energy Metabolism of CD4+ T Cell for Inflammatory Bowel Diseases Treatment

Medicine, Rheumatology and Immunology, Gastroenterology, Life Sciences, Immunology,
Inflammatory Bowel Disease   Mitochondrial CLPP   CD4+ T Cells   Oxidative Phosphorylation   Th17/Treg Balance  

Academic Background Inflammatory Bowel Disease (IBD) is a chronic, relapsing autoimmune disorder primarily comprising Crohn’s Disease (CD) and Ulcerative Colitis (UC). The exact pathogenesis of IBD remains unclear, but it is known that abnormal immune responses play a critical role in its development, particularly the imbalance of CD4+ T cells. The...

Phase Ib Trial of Neoadjuvant Oncolytic Virus OrienX010 and Toripalimab in Resectable Acral Melanoma

Medicine, Rheumatology and Immunology, Basic Medical Sciences, Oncology, Life Sciences, Bioengineering, Immunology, Microbiology,
acral melanoma   neoadjuvant therapy   oncolytic virus   PD-1 inhibitors   tumor microenvironment   recurrence-free survival   safety  

Neoadjuvant Oncolytic Virus OrienX010 Combined with PD-1 Inhibitor Toripalimab for Resectable Acral Melanoma: Phase Ib Clinical Trial Background Acral melanoma (AM) is a highly aggressive subtype of melanoma with a high incidence in the Chinese population, accounting for approximately 40% of melanoma cases. Despite advances in melanoma treatment, c...

Effectiveness of Ocrelizumab in Primary Progressive Multiple Sclerosis: A Multicenter, Retrospective Real-World Study

Medicine, Rheumatology and Immunology, Environmental and Public Health, Basic Medical Sciences, Neurology, Life Sciences, Immunology,
Ocrelizumab   Primary Progressive Multiple Sclerosis   Efficacy   Multicenter Study   Real-World  

Effectiveness of Ocrelizumab in Primary Progressive Multiple Sclerosis: A Multicenter, Retrospective Real-World Study Background and Research Motivation Multiple sclerosis (MS) is a chronic, complex, inflammatory, and degenerative demyelinating disease primarily affecting the central nervous system (CNS). It can lead to neurological impairments in ...

Flow Cytometry Identifies Changes in Peripheral and Intrathecal Lymphocyte Patterns in CNS Autoimmune Disorders and Primary CNS Malignancies

Flow Cytometry Identifies Changes in Peripheral and Intrathecal Lymphocyte Patterns in CNS Autoimmune Disorders and Primary CNS Malignancies

Medicine, Rheumatology and Immunology, Medical Laboratory Science, Neurology, Medical Imaging, Oncology, Life Sciences, Immunology,
flow cytometry   central nervous system   autoimmune disorders   malignancies   lymphocytes   immunophenotyping   early diagnosis  

New Insights into CNS Disease Immunology Mechanisms Revealed by Multidimensional Flow Cytometry In immunological research, understanding the immunopathological mechanisms of central nervous system (CNS) diseases is crucial for early diagnosis and treatment decisions. A study published in Journal of Neuroinflammation in 2024 used multidimensional fl...