Neurons are the fundamental computational units of the brain, and their morphology and connectivity determine the brain’s computational capabilities. The diversity of neurons is driven by a series of waves of gene expression that guide cells through rapid developmental events, ultimately defining neuronal identity. Traditional experiments have show...
Chronic pain is a complex multidimensional experience involving sensory, emotional, and cognitive dimensions. Although traditional analgesic and antidepressant drugs are widely used, more than 50%-60% of chronic pain patients fail to benefit from them. Therefore, finding new treatment strategies has become an urgent need. In recent years, neuromodu...
Background Introduction For a long time, the scientific community has generally believed that mammalian neural stem cells (NSCs) exist only in the central nervous system (CNS), particularly in specific regions of the brain, such as the dentate gyrus of the hippocampus and the subventricular zone near the lateral ventricles. NSCs in these regions ca...
Academic Background Alzheimer’s disease (AD) is the most common neurodegenerative disorder among the elderly, characterized by the pathological features of amyloid-beta (Aβ) deposits and hyperphosphorylated tau protein. Although aging is the most prominent risk factor for AD, the cellular mechanisms linking the decline in neuronal proteostasis to t...
Academic Background Chemical Exchange Saturation Transfer (CEST) Magnetic Resonance Imaging (MRI) is an advanced non-invasive imaging technique that provides detailed molecular information about living tissues. CEST MRI works by selectively saturating exchangeable protons of specific metabolites and transferring this saturation to water molecules, ...
Background Introduction Dementia is a global health issue that significantly impacts patients’ quality of life and places a substantial burden on healthcare systems. Alzheimer’s Disease (AD) and Frontotemporal Dementia (FTD) are two common types of dementia, and their overlapping symptoms make accurate diagnosis and targeted treatment development p...