Prospective Longitudinal Analysis of Physiologic MRI-Based Tumor Habitat Predicts Short-Term Patient Outcomes in IDH-Wildtype Glioblastoma

Medicine, Neurology, Neurosurgery, Medical Imaging, Oncology,
glioblastoma   tumor habitat   physiologic MRI   prognosis prediction   IDH-wildtype  

Prospective Longitudinal Analysis of Physiologic MRI-Based Tumor Habitat Predicts Short-Term Patient Outcomes in IDH-Wildtype Glioblastoma Academic Background Glioblastoma (GBM) is a highly malignant brain tumor characterized by significant intratumoral heterogeneity, which is evident not only in gene expression and histopathology but also in macro...

Comprehensive Evaluation of Pipelines for Classification of Psychiatric Disorders Using Multi-Site Resting-State fMRI Datasets

Comprehensive Evaluation of Pipelines for Classification of Psychiatric Disorders Using Multi-Site Resting-State fMRI Datasets

Medicine, Psychiatry, Neurology, Medical Imaging,
classification biomarker   pipeline   generalization   fMRI   multi-site dataset   major depressive disorder  

Background Introduction The field of psychiatry has long relied on symptoms and medical interviews for diagnosis, lacking objective biomarkers. Resting-state functional magnetic resonance imaging (rs-fMRI) is widely believed to reveal characteristic patterns of brain structure and function, thereby providing potential classification markers for the...

Inhibiting Cell Inspection Points Intervention via Injectable Short Fibers for Reversing Neural Cell Senescence

Medicine, Neurology, Neurosurgery, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
neural cell senescence   inspection point   short fibers   spinal cord   genome homeostasis  

Background Introduction Spinal Cord Injury (SCI) is a significant challenge in the medical field, particularly in terms of neural function recovery. Research indicates that neurons play a crucial role in spinal cord regeneration, but in complex pathological environments, neurons are influenced by various factors, leading to rapid senescence. Senesc...

Bioactive MgO/MgCO3/Polycaprolactone Multi-Gradient Fibers Facilitate Peripheral Nerve Regeneration by Regulating Schwann Cell Function and Activating Wingless/Integrase-1 Signaling

Chemistry, Polymer Chemistry, Materials Chemistry, Materials Science, Metallic Materials, Medicine, Neurology,
magnesium   multi-gradient fibers   Schwann cells   Wnt signaling pathway   peripheral nerve regeneration  

Study on Peripheral Nerve Regeneration Based on Multi-Gradient MgO/MgCO₃/PCL Nanofiber Membranes Academic Background Peripheral nerve defects are a common and complex orthopedic issue in clinical practice, with limited efficacy of current treatments. The insufficient proliferation and dysfunction of Schwann cells within nerve scaffolds are key fact...

Ventilation Practices in Acute Brain Injured Patients and Association with Outcomes: The Ventibrain Multicenter Observational Study

Medicine, Neurology,
mechanical ventilation   acute brain injury   traumatic brain injury   cerebrovascular disease   outcome  

Academic Report on “Ventilation Practices in Acute Brain Injured Patients and Association with Outcomes: The Ventibrain Multicenter Observational Study” Academic Background Mechanical ventilation (MV) is a fundamental component of the intensive care unit (ICU) management of acute brain injury (ABI) patients. However, strong evidence on the best ven...

Disruption of G3BP1 Granules Promotes Mammalian CNS and PNS Axon Regeneration

Medicine, Neurology, Neurosurgery, Life Sciences, Cell Biology,
axon regeneration   central nervous system   G3BP1 granules   peripheral nervous system   neural repair  

Academic Background The regenerative capacity of the nervous system varies significantly between different regions. Axons in the peripheral nervous system (PNS) can regenerate spontaneously after injury, whereas axons in the central nervous system (CNS) lack this ability. This difference makes recovery after CNS injury extremely challenging, especi...