Neuroimaging Meets Neurophysiology: Are There Cortical Somatotopic Motor Maps Outside of the Human Precentral Gyrus?

Medicine, Psychiatry, Neurology, Clinical Psychology, Medical Imaging,
somatotopic motor maps   lateral occipitotemporal cortex   precuneus   functional MRI   motor control  

New Discoveries in Cortical Motor Maps Background Introduction Humans and other primates are capable of performing a wide range of complex body movements, the initiation and control of which rely on multiple cortical and subcortical structures. Among these, the primary motor cortex (M1), located in the precentral gyrus, is the core region for execu...

The Alcatraz-Strategy: A Roadmap to Break the Connectivity Barrier in Malignant Brain Tumours

Medicine, Neurology, Neurosurgery, Oncology,
malignant brain tumours   cellular networks   supramarginal resection   tumour microtubes   cell-to-cell connections   therapeutic strategy   gliomas  

Cellular Network Connectivity and Therapeutic Strategies in Malignant Brain Tumors Academic Background Malignant brain tumors, particularly glioblastoma, are among the most aggressive and lethal tumors in the central nervous system. Despite significant advancements in tumor biology and treatment methods in recent years, the median survival for glio...

Unravelling the Mosaic: Epigenetic Diversity in Glioblastoma

Medicine, Neurology, Neurosurgery, Oncology,
glioblastoma   epigenetics   tumour heterogeneity   DNA methylation   chromatin remodelling   microRNA dysregulation   long noncoding RNA  

Epigenetic Diversity in Glioblastoma Academic Background Glioblastoma is the most common primary malignant brain tumor. Despite decades of research, its prognosis remains extremely poor, with an average survival of only 14 months after diagnosis. The significant heterogeneity of glioblastoma is one of the main reasons for the slow progress in its t...

Microglia and Macrophages in Glioblastoma: Landscapes and Treatment Directions

Medicine, Neurology, Neurosurgery, Oncology, Life Sciences, Immunology,
glioblastoma   microglia   macrophages   tumor microenvironment   immunotherapy   single-cell sequencing   tumor-associated macrophages  

Microglia and Macrophages in Glioblastoma Academic Background Glioblastoma (GBM) is the most common primary malignant tumor of the central nervous system, characterized by high invasiveness and lethality. Despite standard treatments such as surgery, chemotherapy, and radiotherapy, the survival rate of patients remains extremely limited, with a medi...

From Bedside to Bench: New Insights in Epilepsy-Associated Tumors Based on Recent Classification Updates and Animal Models on Brain Tumor Networks

Medicine, Neurology, Neurosurgery, Medical Imaging, Oncology,
low-grade neuroepithelial tumors   epilepsy   in utero electroporation   mouse model   neuronal activity   brain tumors   neuro-oncology  

Latest Research on Epilepsy-Associated Tumors: Classification and Animal Models Background Epilepsy is a common neurological disorder, and some patients are accompanied by brain tumors, particularly low-grade neuroepithelial tumors (LGNTs). These tumors typically grow slowly but are highly associated with drug-resistant epilepsy. Although research ...

The Multifaceted Therapeutical Role of Low-Density Lipoprotein Receptor Family in High-Grade Glioma

Medicine, Neurology, Neurosurgery, Oncology,
Low-Density Lipoprotein Receptor   High-Grade Glioma   Targeted Therapies   Tumorigenesis   Signaling Pathways  

The Multifaceted Therapeutic Role of the Low-Density Lipoprotein Receptor Family in High-Grade Glioma Academic Background High-grade gliomas (HGG) are the most aggressive and prevalent primary brain tumors in the central nervous system (CNS), accounting for approximately 80% of all malignant brain tumors. Among them, glioblastoma (GBM) is the most ...