The Influence of Glioblastoma Differentiation on Blood-Brain Barrier Permeability

Medicine, Neurology, Oncology,
Glioblastoma   Blood-Brain Barrier   Permeability   IL-6   STAT3   Tumor Differentiation   Drug Delivery  

The Impact of Glioblastoma Differentiation on Blood-Brain Barrier Permeability Background Introduction Glioblastoma Multiforme (GBM) is a highly aggressive brain tumor, and its treatment is extremely challenging due to its complex biological characteristics and the presence of the Blood-Brain Barrier (BBB). The BBB is a complex structure composed o...

Relaxation-Exchange Magnetic Resonance Imaging (REXI): A Non-Invasive Imaging Method for Evaluating Trans-Barrier Water Exchange in the Choroid Plexus

Medicine, Neurology, Medical Imaging, Life Sciences, Biophysics,
Magnetic Resonance Imaging   Choroid Plexus   Water Exchange   Non-Invasive   Cerebrospinal Fluid   Biomarker   Steady-State Water Efflux Rate  

Non-Invasive Imaging Technique for Evaluating Trans-Barrier Water Exchange in the Choroid Plexus Background Introduction The choroid plexus (CP) is a critical site for cerebrospinal fluid (CSF) production and an essential component of the blood-cerebrospinal fluid barrier (BCSFB). The CP regulates CSF secretion and absorption, maintaining brain hom...

Poldip2 Mediates Brain Vascular Permeability by Regulating ROS-Mediated ZO-1 Phosphorylation and Localization at the Interendothelial Border

Medicine, Neurology, Life Sciences, Cell Biology,
blood–brain barrier   Poldip2   ZO-1   reactive oxygen species   brain endothelial cells  

POLDIP2 Regulates Cerebral Vascular Permeability by Modulating ROS-Mediated ZO-1 Phosphorylation and Localization Background The blood-brain barrier (BBB) is a critical component of the central nervous system (CNS), composed of brain endothelial cells, astrocytes, pericytes, and neurons. Brain endothelial cells form a continuous physical barrier th...

N88S Seipin-related Seipinopathy: A Lipidopathy Associated with Loss of Iron Homeostasis

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
lipid droplet   seipin   misfolding   seipinopathy   lipidopathy   proteinopathy   inositol   iron  

N88S Seipin-related Seipinopathy is a Lipidopathy Associated with Loss of Iron Homeostasis Academic Background Seipin is a protein encoded by the human BSCL2 gene and the yeast SEI1 gene, forming an endoplasmic reticulum (ER)-bound homo-oligomer. This oligomer plays a crucial role in targeting ER-lipid droplet (LD) contact sites, facilitating the d...

Induction of Tertiary Lymphoid Structures in the Glioma Microenvironment and Their Role in Anti-Glioma Immunity

Medicine, Neurology, Oncology, Life Sciences, Immunology,
glioma   tertiary lymphoid structures   immunotherapy   tumor microenvironment   Toll-like receptor agonists  

Induction of Tertiary Lymphoid Structures in Glioma Immunotherapy and Their Anti-Tumor Immune Effects Background Introduction Glioma is a highly malignant brain tumor characterized by limited lymphocyte infiltration in the tumor microenvironment (glioma microenvironment, GME), presenting an “immune desert” state. This characteristic makes glioma in...

Wnt/β-catenin Signaling is Critical for the Tumorigenesis of Choroid Plexus Tumors

Medicine, Pediatrics, Neurology, Oncology, Life Sciences,
choroid plexus tumors   Wnt/β-catenin signaling   tumorigenesis   chromosomal instability   3D model   APC gene   GSK3β inhibitor  

The Critical Role of Wnt/β-catenin Signaling in Choroid Plexus Tumorigenesis Background Introduction The choroid plexus (CHP) is a secretory epithelial structure located in the brain ventricles, primarily responsible for the secretion of cerebrospinal fluid (CSF) and the establishment of the blood-CSF barrier. Choroid plexus tumors (CPTs) are rare ...