A Glucocorticoid Spike Derails Muscle Repair to Heterotopic Ossification After Spinal Cord Injury

A Glucocorticoid Spike Derails Muscle Repair to Heterotopic Ossification After Spinal Cord Injury

Academic Background and Problem Statement Neurogenic Heterotopic Ossification (NHO) is a pathological condition where ectopic bone tissue forms in muscles following severe central nervous system (CNS) injuries, such as spinal cord injury (SCI), traumatic brain injury (TBI), or stroke. NHO not only impairs motor function but can also lead to joint s...

Perceived Memory Credibility: The Role of Details

Perceived Memory Credibility: The Role of Details Academic Background In daily life, people often share personal memories to convey information, influence others, or entertain. However, distinguishing between credible and non-credible memory narratives remains a complex issue. Although forensic science has identified factors such as race, age, and ...

The Relationship Between Cancer Risk and Epigenetic Age Acceleration After Stroke

Study on the Association Between Long-Term Cancer Risk and Epigenetic Age in Stroke Survivors Background and Significance Cancer and stroke are leading global causes of morbidity and mortality, with their association being increasingly recognized. Statistics show that about 6% of cancer patients experience a stroke during their lifetime, while stro...

Effectiveness of Ocrelizumab in Primary Progressive Multiple Sclerosis: A Multicenter, Retrospective Real-World Study

Effectiveness of Ocrelizumab in Primary Progressive Multiple Sclerosis: A Multicenter, Retrospective Real-World Study Background and Research Motivation Multiple sclerosis (MS) is a chronic, complex, inflammatory, and degenerative demyelinating disease primarily affecting the central nervous system (CNS). It can lead to neurological impairments in ...

Assessing Sustained B-Cell Depletion and Disease Activity in a French Multiple Sclerosis Cohort Treated by Long-Term IV Anti-CD20 Antibody Therapy

Long-term Intravenous Anti-CD20 Antibody Therapy Assessment in a French Multiple Sclerosis Cohort Background and Research Motivation Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease affecting the central nervous system, leading to varying degrees of physical and cognitive impairment. Recent Phase II and III clinical trials of...

Optimized Nutrition in Mitochondrial Disease Correlates to Improved Muscle Fatigue, Strength, and Quality of Life

Optimized Nutritional Interventions Improve Muscle Fatigue, Strength, and Quality of Life in Patients with Primary Mitochondrial Disease Background Introduction Primary mitochondrial disease (PMD) encompasses a group of disorders caused by mutations in mitochondrial DNA or nuclear DNA, affecting systemic energy metabolism. The prevalence is approxi...