Botulinum Neurotoxin Serotype A Inhibited Ocular Angiogenesis through Modulating Glial Activation via SOCS3

Medicine, Neurology, Ophthalmology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Botulinum Neurotoxin Serotype A   Choroidal Neovascularization   Age-Related Macular Degeneration   Glial Activation   Müller Activation   Microglial Activation   SOCS3  

Academic Background Age-related macular degeneration (AMD) is a major cause of central vision loss among the elderly, particularly in its neovascular (NV) form, where choroidal neovascularization (CNV) leads to rapid and severe vision loss. Current AMD treatments primarily rely on intravitreal injections of anti-vascular endothelial growth factor (...

The Influences of APOE Isoforms on Endothelial Adherens Junctions and Actin Cytoskeleton Responding to MCRP

Medicine, Geriatrics, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
APOE   Monomeric C-reactive protein   Endothelial cells   Cytoskeleton   Alzheimer's disease   Cerebrovascular   F-actin  

Research Background Alzheimer’s Disease (AD) is a common neurodegenerative disorder characterized by the deposition of amyloid-beta (Aβ) plaques and abnormal phosphorylation of tau protein. Recent studies have increasingly highlighted the role of cerebrovascular alterations in the pathogenesis of AD. Specifically, endothelial cell damage and inflam...

FBXL16: A New Regulator of Neuroinflammation and Cognition in Alzheimer’s Disease through the Ubiquitination-Dependent Degradation of Amyloid Precursor Protein

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
FBXL16   ubiquitination   Alzheimer’s disease   neuroprotection   amyloid precursor protein  

FBXL16: A New Regulator of Neuroinflammation and Cognition in Alzheimer’s Disease through Ubiquitination-Dependent Degradation of Amyloid Precursor Protein Academic Background Alzheimer’s Disease (AD) is an age-related neurodegenerative disorder characterized by progressive cognitive decline. With the global aging population, the incidence of neuro...

Plasma GFAP and p-tau-181 Association with Synaptic Density at 18F-SynVest-1 PET Imaging

Medicine, Neurology, Medical Imaging,
Alzheimer's disease   synaptic density   PET imaging   plasma biomarkers   neuroinflammation  

Association of Plasma GFAP and p-tau-181 with Synaptic Density in Alzheimer’s Disease Academic Background Alzheimer’s Disease (AD) is a multifactorial neurodegenerative disorder characterized by the accumulation of amyloid-β (Aβ) plaques and tau protein aggregates in the brain. Recent research has shown that multiple factors are involved in the dev...

Aquaporin-4 Immunoglobulin G–Seropositive Neuromyelitis Optica Spectrum Disorder MRI Characteristics: Data Analysis from the International Real-World PAMRINO Study Cohort

Medicine, Neurology, Medical Imaging,
Neuromyelitis Optica Spectrum Disorder   Aquaporin-4   MRI Characteristics   International Study   Central Nervous System Lesions  

Research Background Neuromyelitis Optica Spectrum Disorder (NMOSD) is an autoimmune central nervous system disease characterized by severe onset and relapse events, including optic neuritis, longitudinally extensive transverse myelitis (LETM), brainstem and/or hypothalamic syndromes, and encephalitis. Most patients have serum immunoglobulin G (IgG)...

Alterations in Volume and Resting-State Functional Connectivity Detected at Brain MRI in Individuals with Opioid Use Disorder

Medicine, Psychiatry, Neurology, Medical Imaging,
Opioid Use Disorder   Brain MRI   Resting-State Functional Connectivity   Neuroimaging   Structural Alterations   Functional Alterations   Brain Volume  

Multimodal Neuroimaging Study of Structural and Functional Brain Alterations in Individuals with Opioid Use Disorder Academic Background Opioid Use Disorder (OUD) is a complex chronic condition that has multifaceted negative impacts on an individual’s life and is closely associated with an increased risk of mortality. In 2021, over 80,000 deaths in...