Determining Risk Features for Medulloblastoma in the Molecular Era

Medicine, Pediatrics, Neurology, Oncology,
medulloblastoma   molecular classification   risk stratification   radiation therapy   methylation profiling   chemotherapy   survival rate  

Advances in Risk Stratification and Treatment Strategies for Medulloblastoma Background Medulloblastoma is a common malignant brain tumor in children, with significant differences in treatment and prognosis depending on its molecular subtypes. In recent years, advances in molecular biology have revealed that medulloblastoma can be further divided i...

Structural Variant Allelic Heterogeneity in MECP2 Duplication Syndrome Provides Insight into Clinical Severity and Variability of Disease Expression

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Genetics,
MECP2 duplication syndrome   structural variant   allelic heterogeneity   clinical severity   disease expression   genomic rearrangement   phenotypic traits  

Study of Structural Variation in MECP2 Duplication Syndrome and Its Phenotypic Variability Academic Background MECP2 Duplication Syndrome (MRXSL) is an X-linked genomic disorder primarily caused by an increase in the copy number of the MECP2 gene on the X chromosome. This condition predominantly affects males, and its clinical features vary widely,...

Days-Old Zebrafish Rapidly Learn to Recognize Threatening Agents Through Noradrenergic and Forebrain Circuits

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Biophysics,
zebrafish   learning   noradrenergic   forebrain circuits   threat recognition   neural mechanisms   young animals  

This study explores the necessity of quickly recognizing and avoiding predators in the natural environment, which is crucial for juvenile animals due to their increased vulnerability to predators. However, it remains unclear whether neonatal vertebrates can rapidly acquire such skills and the underlying neural mechanisms. Zebrafish, a widely used m...

Layer-Specific Anatomical and Physiological Features of the Retina’s Neurovascular Unit

Medicine, Neurology, Ophthalmology, Life Sciences, Cell Biology, Biochemistry, Biophysics,
retina   neurovascular unit   Müller glia   calcium signaling   retinitis pigmentosa  

Academic Report on the Study of Layer-Specific Anatomical and Physiological Characteristics of the Retinal Neurovascular Unit Background and Problem Statement Retinal processing, similar to all neural computations, is metabolically expensive and involves the dynamic regulation of blood flow, known as neurovascular coupling (NVC). The retina is supp...

Impaired Pheromone Detection and Abnormal Sexual Behavior in Female Mice Deficient for AncV1R

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry,
pheromone   female mice   AncV1R   sexual behavior   stress response   neural activity   mating behavior  

Report on the Study of the Impact of ANCV1R Gene Deficiency on Pheromone Detection and Sexual Behavior in Mice Background Introduction In mammals, pheromones are crucial chemical signals that regulate social and sexual behaviors. Pheromone detection is mediated by the vomeronasal organ (VNO), which uses vomeronasal sensory neurons (VSNs) to recogni...

A Wearable Echomyography System Based on a Single Transducer

Engineering, Electrical Engineering, Information Science, Artificial Intelligence, Medicine, Respiratory System, Neurology, Medical Imaging, Life Sciences, Bioengineering,
wearable devices   echomyography   single transducer   deep learning   muscle activity monitoring   wireless circuit   ultrasound  

Innovative Advances in Wearable Single-Transducer Echomyography Systems: From Muscle Dynamics Monitoring to Complex Gesture Tracking Academic Background and Research Significance In recent years, wearable electronic devices have garnered significant attention for their enormous potential in health monitoring and human-machine interaction. Electromy...