Alterations in Volume and Resting-State Functional Connectivity Detected at Brain MRI in Individuals with Opioid Use Disorder

Medicine, Psychiatry, Neurology, Medical Imaging,
Opioid Use Disorder   Brain MRI   Resting-State Functional Connectivity   Neuroimaging   Structural Alterations   Functional Alterations   Brain Volume  

Multimodal Neuroimaging Study of Structural and Functional Brain Alterations in Individuals with Opioid Use Disorder Academic Background Opioid Use Disorder (OUD) is a complex chronic condition that has multifaceted negative impacts on an individual’s life and is closely associated with an increased risk of mortality. In 2021, over 80,000 deaths in...

MR Spectroscopy to Assess Muscle Mitochondrial Dysfunction in Long COVID

Medicine, Neurology, Medical Imaging,
Long COVID   Mitochondrial Dysfunction   MR Spectroscopy   Fatigue   Muscle Metabolism  

Report on the Use of MR Spectroscopy to Assess Muscle Mitochondrial Dysfunction in Long COVID Academic Background The COVID-19 pandemic has had a profound impact on global health, with many patients experiencing prolonged symptoms even after recovery, commonly referred to as “Long COVID” or “Post–COVID-19 Condition” (PCC). These symptoms include fa...

Fabrication and In Vivo Testing of a Sub-mm Duckbill Valve for Hydrocephalus Treatment

Medicine, Neurology, Neurosurgery, Life Sciences, Bioengineering,
hydrocephalus   duckbill valve   intracranial pressure   cerebrospinal fluid   shunting systems  

Fabrication and In Vivo Testing of a Sub-mm Duckbill Valve for Hydrocephalus Treatment Academic Background Hydrocephalus is a complex pathological condition characterized by the accumulation of cerebrospinal fluid (CSF) in the cranium due to an imbalance between CSF production and absorption. This accumulation leads to increased intracranial pressu...

Robust Self-Supervised Denoising of Voltage Imaging Data Using CellMincer

Medicine, Neurology, Medical Imaging, Life Sciences, Biophysics,
voltage imaging   self-supervised learning   denoising algorithm   deep learning   signal processing  

Academic Background Voltage imaging is a powerful technique for studying neuronal activity, but its effectiveness is often constrained by low signal-to-noise ratios (SNR). Traditional denoising methods, such as matrix factorization, impose rigid assumptions about noise and signal structures, while existing deep learning approaches fail to fully cap...

Evaluation of the Redox Alteration in Duchenne Muscular Dystrophy Model Mice Using In Vivo DNP-MRI

Medicine, Neurology, Medical Imaging,
Duchenne Muscular Dystrophy   Redox Status   In Vivo DNP-MRI   Inflammation   Mitochondrial Function  

Academic Background Duchenne Muscular Dystrophy (DMD) is a genetic muscular disorder and the most common type of muscular dystrophy in Japan. DMD is caused by a mutation in the dystrophin gene on the X chromosome, leading to the absence or defect of the dystrophin protein in muscle fibers. This results in a cascade of events, including increased mu...

Spatial Transcriptomic Clocks Reveal Cell Proximity Effects in Brain Ageing

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
brain ageing   spatial transcriptomics   cell proximity effects   T cells   neural stem cells  

Spatial Transcriptomic Clocks Reveal Cell Proximity Effects in Brain Aging Academic Background With aging, cognitive function declines, and the risk of neurodegenerative diseases significantly increases. Brain aging is a complex process accompanied by numerous cellular changes. However, how aging cells affect neighboring cells and how this contribu...