Functional Screen Identifies RBM42 as a Mediator of Oncogenic mRNA Translation Specificity

Medicine, Oncology, Life Sciences, Cell Biology,
oncogene   translational control   pancreatic ductal adenocarcinoma   RBM42   MYC  

The occurrence and progression of cancer are closely related to the expression of oncogenes, and the regulation of oncogene expression is a complex process. Among these mechanisms, the role of translation control in oncogene expression has gradually gained attention. MYC is a key oncogene that is overexpressed in various cancers, particularly in pa...

Synthesis and Characterization of Pyrogallol Silver Nanoparticles and Pyrogallol Nanocomposites and Their Effects on Radiation-Induced Toxicity in HEK293 Cells

Chemistry, Nanoscience, Medicinal Chemistry, Medicine, Oncology, Life Sciences, Bioengineering,
nanoparticles   nanocomposites   radiation   cell protection   anti-inflammatory   apoptosis   biomedical applications  

Academic Background Cancer is a complex and highly prevalent disease worldwide, causing nearly 10 million deaths annually. Early diagnosis and effective treatment are crucial for improving patient survival rates. Current cancer treatment modalities include surgery, chemotherapy, radiotherapy, and immunotherapy. Among these, radiotherapy is a critic...

A Novel Formulation of Docetaxel-Containing Micelle Surface Modified with Metronidazole to Target Tumor Hypoxia

Chemistry, Medicinal Chemistry, Medicine, Oncology, Life Sciences, Bioengineering,
tumor hypoxia   metronidazole   active targeting   micelle   docetaxel  

Background Introduction Cancer is one of the leading causes of death globally, and despite significant progress in treatment, the complexity of tumors, particularly tumor hypoxia, remains a major obstacle to successful therapy. Hypoxic regions are prevalent in solid tumors, where oxygen concentrations are significantly lower than in normal tissues ...

Effectiveness of Chitosan Nanoparticles as a Radioprotective Agent Against Gamma-Induced Changes in the Histology and Biochemistry of Parotid Glands

Chemistry, Nanoscience, Medicine, Oncology, Life Sciences, Biochemistry, Bioengineering,
chitosan nanoparticles   radioprotection   parotid glands   oxidative stress   survival rate  

Cancer is one of the leading causes of death worldwide. Radiotherapy, as a crucial method for cancer treatment, effectively kills cancer cells but also damages normal tissues, especially sensitive tissues such as salivary glands. The oxidative stress and inflammatory reactions induced by radiotherapy are the primary causes of salivary gland dysfunc...

Endothelial Cells Stably Infected with Recombinant Kaposi’s Sarcoma-Associated Herpesvirus Display Distinct Viscoelastic and Morphological Properties

Medicine, Infectious Diseases, Oncology, Life Sciences, Cell Biology, Bioengineering,
cell mechanics   KSHV   mechanotyping   passive microrheology   vascular   lymphatic   biomedical engineering  

Kaposi’s sarcoma-associated herpesvirus (KSHV) is a γ-herpesvirus that primarily infects endothelial cells and leads to the development of Kaposi’s sarcoma (KS), especially in people living with HIV. Kaposi’s sarcoma is a malignant tumor characterized by endothelial cell proliferation, typically presenting as cutaneous lesions. After infecting endo...

High-Throughput Metabolomic Profiling of Skin Lesions: Comparative Study of Cutaneous Squamous Cell Carcinoma, Basal Cell Carcinoma, and Normal Skin via E-Biopsy Sampling

Medicine, Medical Laboratory Science, Oncology, Life Sciences, Bioengineering,
high-throughput metabolomics   metabolomic profiling   cutaneous squamous cell carcinoma   basal cell carcinoma   e-biopsy   skin cancer diagnosis   molecular analysis  

Academic Background Cutaneous Squamous Cell Carcinoma (CSCC) and Basal Cell Carcinoma (BCC) are among the most common types of skin cancer globally. Although the mortality rates of these cancers are relatively low, their incidence has been increasing year by year, significantly impacting patients’ quality of life and potentially leading to prematur...