Meningioma: International Consortium on Meningiomas (ICOM) Consensus Review on Scientific Advances & Treatment Paradigms for Clinicians, Researchers, and Patients

Medicine, Neurosurgery, Oncology,
meningioma   review   clinical treatment   research advances   consensus  

Meningiomas are the most common primary intracranial tumors in adults, and their incidence is rising with an aging population and the widespread use of neuroimaging examinations. While most meningiomas are benign, a small portion exhibit biological invasiveness, leading to severe neurological complications and death. In recent years, significant pr...

EDA2R reflects the acute brain response to cranial irradiation

Medicine, Neurosurgery, Oncology,
EDA2R   biomarker   cranial irradiation   neurocognitive impairments   liquid biopsies  

EDA2R Elevation in Liquid Biopsy Reflects Acute Brain Injury after Cranial Radiation Background Cranial radiation therapy is the standard treatment for advanced brain tumors and metastases, but it leads to devastating neurocognitive impairments, especially in childhood cancer survivors. As the number of childhood brain cancer survivors continues to...

NF1 mutation-induced neuronal hyperexcitability drives murine optic glioma growth and can be targeted by lamotrigine treatment

Medicine, Neurology, Oncology, Life Sciences, Immunology, Genetics,
NF1 gene mutation   neuronal hyperexcitability   optic glioma   murine models   lamotrigine treatment  

Title: Treating Low-Grade Optic Pathway Glioma by Inhibiting Neuronal Activity Introduction: Optic pathway glioma (OPG) is a low-grade glioma commonly found in children with neurofibromatosis type 1 (NF1). NF1 is a common neurocutaneous syndrome with an incidence of approximately 1⁄3000. Although OPG is a low-grade tumor, it can lead to serious com...

Phase I Trial of Dose Escalation for Preoperative Stereotactic Radiosurgery for Patients with Large Brain Metastases

Medicine, Neurosurgery, Medical Imaging, Oncology,
brain metastases   stereotactic radiosurgery   dose escalation   preoperative radiation  

This is a phase I clinical trial that explored the safety of preoperative single-fraction stereotactic radiosurgery (SRS) with dose escalation for patients with brain metastases. The background of this study is that for brain metastases larger than 2cm in diameter, surgery alone or single-fraction SRS alone is difficult to achieve ideal local contr...

Circulating Extracellular Vesicles as Biomarker for Diagnosis, Prognosis and Monitoring in Glioblastoma Patients

Medicine, Neurology, Neurosurgery, Medical Imaging, Oncology,
extracellular vesicles   biomarker   glioblastoma   diagnosis   prognosis  

This academic paper reports a study on exosomes in patients with glioblastoma. The study explored the potential application of exosomes as biomarkers in the diagnosis, prognosis, and treatment response monitoring of glioblastoma. Academic Background: Glioblastoma is an invasive brain tumor, and despite comprehensive treatments such as surgery, chem...

Radical surgical resection with molecular margins is associated with improved survival in IDH wildtype GBM

Medicine, Basic Medical Sciences, Neurosurgery, Oncology, Life Sciences, Genetics,
glioblastoma   TERT promoter mutation   surgical margin   radical resection   survival  

In this research paper from the journal Neuro-Oncology, the researchers investigated the relationship between the residual tumor cells at the resection margin after surgical removal and the progression-free survival (PFS) and overall survival (OS) in patients with wildtype isocitrate dehydrogenase (IDH wildtype) glioblastoma (GBM). The authors are ...