Safety and Efficacy of Intrathecal Drug Delivery Pumps for Intractable Pain in Cancer Patients Introduction Pain management in cancer patients is a critical issue in palliative care, as clinicians strive to improve patients’ quality of life and alleviate their suffering. Most cancer patients experience cancer-related pain, and 30%-40% of them suffe...

Study on the Extent of Resection Threshold in Different Molecular Subtypes of Newly Diagnosed IDH-wildtype Glioblastoma Introduction Glioblastoma (GBM) is the most common malignant brain tumor in adults. Although surgical resection, radiotherapy, and chemotherapy are the current standard treatment regimens, the prognosis of GBM remains poor, with a...

This study revolves around the protein arginine methyltransferase PRMT9, revealing its important role in acute myeloid leukemia (AML) and its potential as an anticancer target. Researchers found that PRMT9 expression levels were significantly elevated in AML stem cells and leukemic cells. Through gene editing and chemical probes, they discovered th...

This study utilized a machine learning framework to explore the underlying cell states and cellular ecosystems constituting soft tissue sarcomas, and associated them with patient prognosis and response to immunotherapy. Research Background: Soft tissue sarcomas are rare and highly heterogeneous malignancies of connective tissues, with limited syste...

Overcoming Acquired Resistance in Colorectal Cancer by Targeting LGR4 Research Background: Acquired drug resistance is a major obstacle in cancer treatment and a leading cause of cancer-related deaths. However, the mechanisms of resistance are diverse, and how to specifically target resistant cancer cells remains a significant clinical challenge. A...

Utilizing Dynamic Single-Cell Analysis to Discover a Clinically Effective Chimeric Antigen Receptor T-Cell Subset for Treating Diffuse Large B-Cell Lymphoma Research Background Chimeric antigen receptor (CAR) T-cell therapy has been proven to be an effective treatment for B-cell malignancies. However, it remains challenging to predict individual cl...