LGALS9B stabilizes EEF1D protein and activates the PI3K/AKT signaling pathway to promote gastric cancer occurrence and metastasis

Medicine, Gastroenterology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
gastric cancer   LGALS9B   EEF1D   PI3K/AKT signaling pathway   tumor metastasis   cell proliferation   molecular mechanism  

lgals9b Stabilizes eef1d Protein and Activates the PI3K/AKT Signaling Pathway to Promote Gastric Cancer Occurrence and Metastasis Academic Background Gastric cancer ranks as the fifth most prevalent cancer globally, with over one million new cases diagnosed annually. Due to late detection, it exhibits a high mortality rate and is the fourth leading...

The Antitumor Activity of TGFβ-Specific T Cells is Dependent on IL-6 Signaling

Medicine, Rheumatology and Immunology, Oncology, Life Sciences, Cell Biology, Immunology,
TGFβ   IL-6   immunosuppression   tumor microenvironment   vaccines  

Review of the Study on the Relationship Between IL-6 Signaling and the Anti-Tumor Activity of TGFβ-Specific T Cells Background and Significance of the Study Interleukin-6 (IL-6) is a pleiotropic cytokine that plays a critical role in inflammation and hematopoiesis. However, its role in the immune system is context-dependent. While it has pro-inflam...

Spatial Transcriptome Profiling Identifies DTX3L and BST2 as Key Biomarkers in Esophageal Squamous Cell Carcinoma Tumorigenesis

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
Esophageal squamous cell carcinoma   Tumorigenesis   Spatial transcriptome   Single-cell transcriptome   Tumor-associated macrophage   Polarization   Spatial biomarker   Functional studies  

Digital Spatial Transcriptomics Highlights DTX3L and BST2 as Crucial Biomarkers in Esophageal Squamous Cell Carcinoma Tumorigenesis Background and Research Question Esophageal cancer (EC) remains a globally prevalent malignant disease with high incidence and mortality rates. Esophageal squamous cell carcinoma (ESCC), the most common histological su...

Patterns of Genomic Instability in Ovarian Cancer Patients

Medicine, Obstetrics and Gynecology, Oncology, Life Sciences, Biochemistry, Genetics,
ovarian cancer   genomic instability   PARP inhibitors   homologous recombination deficiency   clinical trials   BRCA mutations   precision medicine  

Background and Research Question Ovarian cancer, as a fatal gynecological malignancy, has become the focus of recent studies, particularly on expanding the feasibility of targeted therapies. The introduction of poly(ADP-ribose) polymerase (PARP) inhibitors has marked a groundbreaking treatment option for ovarian cancer, especially for patients with...

SIRCLE Model Reveals Mechanisms of Phenotype Regulation in Renal Cancer

Medicine, Urology, Nephrology, Oncology,
multi-omics integration   phenotype regulation   machine learning   variational autoencoder   clear cell renal cell carcinoma   pancan   metabolism  

Executive Report on the Study of ccRCC Regulatory Mechanisms Using the SIRCLE Model Background Overview Clear Cell Renal Cell Carcinoma (ccRCC) is the most prevalent form of kidney cancer, accounting for 70% of renal malignancies. The development and progression of ccRCC involve intricate remodeling of the kidney epigenome, transcriptome, proteome,...

Integrated Analyses of Multi-Omic Data Reveal Metabolic Vulnerability as a Novel Therapeutic Target in Lung Cancer Brain Metastases

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
Lung cancer brain metastases   Metabolic vulnerability   Tumor immune microenvironment   Multi-omic analysis   Mitochondrial metabolism  

Report on the Multi-Omics Study of Lung Cancer Brain Metastases (LC-BMs) Academic Background Lung cancer is one of the most prevalent and deadly cancers worldwide. Lung cancer brain metastases (LC-BMs) are a common complication in patients with lung cancer and are associated with poor prognosis. Despite advances in lung cancer therapies, the standa...