Integrated Analyses of Multi-Omic Data Reveal Metabolic Vulnerability as a Novel Therapeutic Target in Lung Cancer Brain Metastases

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
Lung cancer brain metastases   Metabolic vulnerability   Tumor immune microenvironment   Multi-omic analysis   Mitochondrial metabolism  

Report on the Multi-Omics Study of Lung Cancer Brain Metastases (LC-BMs) Academic Background Lung cancer is one of the most prevalent and deadly cancers worldwide. Lung cancer brain metastases (LC-BMs) are a common complication in patients with lung cancer and are associated with poor prognosis. Despite advances in lung cancer therapies, the standa...

Genome-aware annotation of CRISPR guides validates targets in variant cell lines and enhances discovery in screens

Medicine, Oncology, Life Sciences, Cell Biology, Bioengineering, Genetics,
CRISPR   genome annotation   bioinformatics   computational biology   software tool  

Genomic Medicine and Re-annotation of CRISPR Guides: Application and Validation of the EXORCISE Algorithm Academic Background The advent of CRISPR-Cas9 technology has revolutionized genetic screening, particularly in studying gene essentiality and chemo-genetic interactions. By designing guide RNAs (gRNAs) that target specific genes, the CRISPR-Cas...

Critical and Differential Roles of eIF4A1 and eIF4A2 in B-cell Development and Function

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
RNA helicase   eIF4A   ribosome biogenesis   translation   B cell  

Critical and Differential Roles of eIF4A1 and eIF4A2 in B-Cell Development and Function Academic Background In mammalian cells, translation initiation is a crucial step in protein synthesis, where the eukaryotic initiation factor 4A (eIF4A) plays a pivotal role. eIF4A is an ATP-dependent RNA helicase that unwinds secondary structures in the 5’ untr...

Mapping In Silico Genetic Networks of the KMT2D Tumour Suppressor Gene to Uncover Novel Functional Associations and Cancer Cell Vulnerabilities

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
tumour suppressor genes   KMT2D   genetic networks   synthetic lethality   WRN inhibitors  

Academic Background and Problem Statement Loss-of-Function (LOF) mutations in Tumor Suppressor Genes (TSGs) are prevalent in cancer. However, therapeutic strategies directly targeting these mutations are challenging due to the loss or reduction of encoded protein function, which in normal states plays a role in inhibiting aberrant cell proliferatio...

Integrated Single-Cell Analysis Reveals Distinct Epigenetic-Regulated Cancer Cell States and a Heterogeneity-Guided Core Signature in Tamoxifen-Resistant Breast Cancer

Medicine, Oncology, Life Sciences, Cell Biology, Genetics,
single-cell analysis   epigenetic regulation   breast cancer heterogeneity   tamoxifen resistance   core signature   tumor microenvironment   BMP7  

Integrated Single-Cell Analysis Reveals Distinct Epigenetic-Regulated Cancer Cell States and a Heterogeneity-Guided Core Signature in Tamoxifen-Resistant Breast Cancer Academic Background Breast cancer is one of the most common cancers in women, and endocrine therapy (e.g., tamoxifen) is the standard treatment for estrogen receptor α (ER)-positive ...

AugDiff: Diffusion-Based Feature Augmentation for Multiple Instance Learning in Whole Slide Image

Information Science, Computer Science, Artificial Intelligence, Medicine, Oncology,
feature augmentation   diffusion model   multiple instance learning   whole slide image   computational pathology   deep learning   image generation  

Diffusion-Based Feature Augmentation: A Novel Approach for Multiple Instance Learning in Whole Slide Images Academic Background and Research Motivation In computational pathology, effectively analyzing Whole Slide Images (WSIs) is a burgeoning area of research. WSIs are ultra-high-resolution images with a broad field of view and are widely employed...