Molecular and Clinical Heterogeneity within MYC-Family Amplified Medulloblastoma is Associated with Survival Outcomes: A Multicenter Cohort Study

Medicine, Neurology, Neurosurgery, Oncology,
medulloblastoma   MYC amplification   clinical heterogeneity   molecular subgroups   survival outcomes   high-risk disease   treatment strategies  

Clinical and Biological Heterogeneity in MYC/MYCN-Amplified Medulloblastoma Academic Background Medulloblastoma (MB) is one of the most common malignant brain tumors in children. Despite recent advances in treatment, approximately 30% of patients still die from the disease, and survivors often face long-term treatment-related complications. Amplifi...

Distinct Relapse Patterns Across Molecular Ependymoma Types

Distinct Relapse Patterns Across Molecular Ependymoma Types

Medicine, Neurology, Neurosurgery, Oncology,
ependymoma   relapse patterns   molecular types   intracranial tumors   clinical research  

Study on Relapse Patterns of Intracranial Ependymoma Background Ependymoma (EPn) is a rare but highly heterogeneous central nervous system tumor, particularly common in children. Despite significant advances in the biology and molecular characteristics of ependymoma in recent years, its relapse patterns remain unclear. The timing and location of re...

Determining Risk Features for Medulloblastoma in the Molecular Era

Medicine, Pediatrics, Neurology, Oncology,
medulloblastoma   molecular classification   risk stratification   radiation therapy   methylation profiling   chemotherapy   survival rate  

Advances in Risk Stratification and Treatment Strategies for Medulloblastoma Background Medulloblastoma is a common malignant brain tumor in children, with significant differences in treatment and prognosis depending on its molecular subtypes. In recent years, advances in molecular biology have revealed that medulloblastoma can be further divided i...

Developmental Pluripotency-Associated 4 Increases Aggressiveness of Pituitary Neuroendocrine Tumors by Enhancing Cell Stemness

Medicine, Endocrinology, Oncology, Life Sciences, Cell Biology, Genetics,
pituitary neuroendocrine tumors   cell stemness   Wnt/β-catenin signaling   Dppa4 gene   tumor aggressiveness   epigenetics   stem cell regulation  

The Oncogenic Role of Dppa4 in Pituitary Neuroendocrine Tumors Academic Background Pituitary Neuroendocrine Tumors (PitNETs) are common intracranial tumors that often exhibit hormone-secreting functions and are a significant cause of hypogonadism and infertility in humans. Although most PitNETs can be controlled through surgery and medication, some...

Global Profiling of Alternative Splicing in Non-Small Cell Lung Cancer Reveals Novel Histological and Population Differences

Medicine, Oncology, Life Sciences, Biochemistry, Genetics,
non-small cell lung cancer   alternative splicing   population differences   tumor biology   biomarkers   molecular subtypes   therapeutic targets  

Global Profiling of Alternative Splicing in Non-Small Cell Lung Cancer Reveals Novel Histological and Population Differences Academic Background Lung cancer is one of the most frequently diagnosed cancers in the United States, with non-small cell lung cancer (NSCLC) accounting for the majority of cases. Among NSCLC, lung adenocarcinoma (LUAD) and l...

Mevalonate Kinase Inhibits Anti-Tumor Immunity by Impairing the Tumor Cell-Intrinsic Interferon Response in Microsatellite Instability Colorectal Cancer

Medicine, Oncology, Life Sciences, Immunology,
Mevalonate Kinase   Microsatellite Instability Colorectal Cancer   Interferon Response   Immune Checkpoint Blockade   Cholesterol Metabolism  

Mevalonate Kinase Impairs Anti-Tumor Immunity by Inhibiting the Tumor Cell-Intrinsic Interferon Response in Microsatellite Instability Colorectal Cancer Academic Background Immune checkpoint blockade (ICB) therapy, particularly anti-PD-1 monoclonal antibodies, has been approved for the treatment of microsatellite instability colorectal cancer (MSI ...