PEARL: A Phase Ib/II Biomarker Study of Adding Radiation Therapy to Pembrolizumab Before Neoadjuvant Chemotherapy in HER2-Negative Breast Cancer

Medicine, Oncology, Life Sciences, Immunology,
breast cancer   radiation therapy   Pembrolizumab   neoadjuvant chemotherapy   biomarkers   HER2-negative   tumor-infiltrating lymphocytes  

Academic Background Breast cancer is one of the most common cancers among women worldwide, particularly triple-negative breast cancer (TNBC) and hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) breast cancer, which are known for their aggressive nature and poor prognosis. In recent years, immune checkpoint inh...

Atezolizumab Combined with Platinum and Maintenance Niraparib for Recurrent Ovarian Cancer with a Platinum-Free Interval >6 Months: ENGOT-OV41/GEICO 69-O/ANITA Phase III Trial

Atezolizumab Combined with Platinum and Maintenance Niraparib for Recurrent Ovarian Cancer with a Platinum-Free Interval >6 Months: ENGOT-OV41/GEICO 69-O/ANITA Phase III Trial

Medicine, Obstetrics and Gynecology, Oncology,
Atezolizumab   Platinum-based chemotherapy   Niraparib   Recurrent ovarian cancer   Phase III trial   Platinum-free interval   ENGOT-OV41  

Academic Background Ovarian cancer is one of the most common malignancies of the female reproductive system. Despite recent advancements in treatment, the recurrence rate remains high, particularly in patients with late relapse. Platinum-based chemotherapy (CT) is the standard treatment for ovarian cancer, and poly (ADP-ribose) polymerase (PARP) in...

Increasing Rates of Distant-Stage Breast Cancer at Presentation in U.S. Women

Medicine, Oncology,
breast cancer   distant-stage cancer   incidence rates   U.S. women   COVID-19   screening   racial disparities  

Report on the Increasing Rates of Distant-Stage Breast Cancer in U.S. Women Academic Background Breast cancer is the second leading cause of cancer death among U.S. women, following lung cancer. Although screening mammography has been shown to significantly reduce breast cancer mortality, screening rates in the U.S. remain low, particularly among w...

MRI-Directed Micro-US–Guided Transperineal Focal Laser Ablation for Localized Prostate Cancer: A 1-Year Follow-Up Study

Medicine, Urology, Medical Imaging, Oncology,
prostate cancer   focal laser ablation   micro-US   MRI-guided   transperineal   recurrence rate   functional preservation  

MRI-Guided Micro-US Transperineal Focal Laser Ablation for Localized Prostate Cancer: A 1-Year Follow-Up Study Academic Background Prostate cancer (PCA) is one of the most common malignancies among men worldwide. With the widespread adoption of prostate-specific antigen (PSA) screening, the diagnosis of low-risk prostate cancer has significantly in...

Low-Dose CT Screening in East Asian Women Who Have Never Smoked: Association Between Family History of Lung Cancer and Ground-Glass Nodule Prevalence and Growth

Medicine, Respiratory System, Medical Imaging, Oncology,
Low-dose CT screening   Ground-glass nodules   Family history of lung cancer   Asian women   Lung cancer risk  

Low-Dose CT Screening in East Asian Women Who Have Never Smoked: Association Between Family History of Lung Cancer and Ground-Glass Nodule Prevalence and Growth Academic Background Lung cancer is the leading cause of cancer-related mortality worldwide, and smoking is a well-established risk factor for lung cancer. Low-dose CT (LDCT) is an effective...

NACVI-RADS Scores for Assessing Muscle-Invasive Bladder Cancer Response to Neoadjuvant Immunotherapy with Multiparametric MRI

Medicine, Urology, Medical Imaging, Oncology,
Muscle-Invasive Bladder Cancer   Neoadjuvant Immunotherapy   Multiparametric MRI   NACVI-RADS Scores   Pathologic Complete Response  

Academic Background Muscle-invasive bladder cancer (MIBC) is a highly aggressive malignancy. The standard treatment typically involves cisplatin-based neoadjuvant chemotherapy (NAC) or immunotherapy, followed by radical cystectomy (RC) and bilateral pelvic lymph node dissection. However, radical cystectomy significantly impacts patients’ quality of...